Yazar "Kara, Murat" için listeleme
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Açık spinal disrafizmli hastalarda ve sağlıklı annelerinde MTHFR c677t, MTHFR a1298c, Pai-1, Faktör II ve faktör V polimorfizminin değerlendirilmesi
Bu çalışmada açık spinal disrafizmli hastalar ile sağlıklı annelerinde MTHFR c677t, MTHFR a1298c, PAI-1, Faktör II ve Faktör V gen polimorfizmleri incelenerek, mevcut genetik risk faktörlerinin çocukta nöral tüp defekti ... -
The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells
Bayram, D.; Çetin, Esin Sakallı; Kara, Murat; Özgöçmen, M.; Candan, I. A. (Sage Publications Ltd, 2017)Background: Silibinin is a bioactive flavonolignan extracted from milk thistle, known as Silybum marianum. Silibinin exerts strong antiproliferative, proapoptotic, and anti-inflammatory effects. Many studies have shown ... -
Application of talcum powder, trichloroacetic acid and silver nitrate in female rats for non-surgical sterilization: evaluation of the apoptotic pathway mRNA and miRNA genes
Yumrutaş, Önder; Kara, Murat; Atılgan, Remzi; Kavak, Salih Burçin; Bozgeyik, İbrahim; Sapmaz, Ekrem (Wiley, 2015)There are several methods used for non-surgical sterilization in birth control including quinacrine, trichloroacetic acid (TCA), erythromycin, tetracycline, silver nitrate and talcum powder. Among these, talcum powder, TCA ... -
Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis
Kara, Murat; Yolbaş, Servet; Şahin, Cem; Koca, Süleyman Serdar (Aves, 2017)Objective: Sirtuins (SIRTs) play a prominent role in metabolism, apoptosis, aging, inflammation, and epigenetics. Inflammation, apoptosis, and epigenetics are pathogenic issues in rheumatoid arthritis (RA). This study aimed ... -
Chromosomal Translocation t (10; 19) (q11.2; q13.4) in an Infertile Male
Kara, Murat; Sen, Askin; Cetin, Esin Sakalli; Kargun, Kursat (Aves, 2014)Chromosomal rearrangements are usually associated with male factor infertility. We report here a 34-year-old man suffering from primary infertility for 15 years. The cytogenetic analysis and investigation of Y-chromosome ... -
Cinsel istismar olgularında monoamin oksidaz A enziminin gen polimorfizmi ve davranım bozukluğu gelişmesi ile arasındaki ilişkinin incelenmesi
Özgür, Börte Gürbüz; Aksu, Hatice; Kara, Murat (2017)Amaç: Bu çalışmanın amacı cinsel istismar mağduru olan olgularda davranım bozukluğu (DB) geliştiren ve geliştirmeyen gruplar arasında monoamin oksidaz A (MAO-A) gen polimorfizmi açısından ilişki olup olmadığını incelemektir. ... -
Determination of the effects on learning and memory performance and related gene expressions of clothianidin in rat models
Özdemir, Hasan Hüseyin; Kara, Murat; Yumrutaş, Önder; Üçkardeş, Fatih; Eraslan, Ersen; Demir, Caner F.; Bal, Ramazan (Springer, 2014)Clothianidin (CLO) is one of the pesticides used to protect against insects, and its potential toxic effects on cognitive functions are not clearly known. This study aims to evaluate the possible effects of dose-dependent ... -
Differential Expression and in Silico Functional Analysis of Plasma MicroRNAs in the Pathogenesis of Non-segmental Vitiligo
Demir Pektaş, Suzan; Kara, Murat; Doğan, Gürsoy; Pektaş, Mehmet Bilgehan; Baloğlu, Mehmet Cengiz; Sadi, Gökhan (PMC, 2023)Vitiligo is a disease characterized by acquired depigmentation, white macules, and patches on the skin due to the dysfunction of epidermal melanocytes. In this study, we attempt to profile the microRNA (miRNA) expression ... -
Differential Expression of MicroRNAs in Chronic Obstructive Pulmonary Disease
Kara, Murat; Kirkil, Gamze; Kalemci, Serdar (Wroclaw Medical Univ, 2016)Background. This study aimed to investigate the associations of miRNA with COPD patients. Objectives. Chronic obstructive pulmonary disease (COPD) is characterized by progressive and largely irreversible airflow limitation. ... -
Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma
Kara, Murat; Yumrutaş, Önder; Özcan, Önder; Çelik, Özgür İlhan; Bozgeyik, Esra; Bozgeyik, İbrahim; Taşdemir, Şener (Elsevier Science Bv, 2015)Colorectal cancer is one of the frequently seen malignancies in the world. To date, several oncogenes and tumor suppressor genes have been identified and linked to colorectal cancer pathogenesis. Although recent advances ... -
Does MiRNA gene expression predict gastric cancer stage and localization?
Özcan, Önder; Belli, Ahmet Korkut; Kayılıoğlu, Selami Ilgaz; Çelik, Özgür İlhan; Kaplan, Mehmet; Kara, Murat; Polat, Murat (2019)Gastric cancer comprises 10% of all cancers in the world and is rarely seen before the age of 30. Different genetic interactions or molecular changes like e-cadherin, P16, APC, c-erb B2, c-met, ras, or c-myc have been ... -
Double trizomiye (48,XXX,+21) sahip Down sendromlu bir çocuk: Olgu sunumu
Double trizomi, iki sayısal komozom anomalisinin birlikte bulunmasıdır. Bu olguların çoğu spontan düşükle sonuçlandığından nadir görülen bir durumdur. Double trizomi, genellikle ya birinci veya ikinci mayoz bölünme sırasında ... -
Ectodermal dysplasia-skin fragility syndrome with a new mutation
Alataş, Emine Tuğba; Kara, Asude; Kara, Murat; Doğan, Gürsoy; Baysal, Onur (Wolters Kluwer Medknow Publications, 2017) -
The effects of novokinin, an AT2 agonist, on blood pressure, vascular responses, and levels of ADMA, NADPH oxidase, and Rho kinase in hypertension induced by NOS inhibition and salt
Mutlu, Emre; Ilhan, Selcuk; Onat, Elif; Kara, Murat; Sahna, Engin (Tubitak Scientific & Technical Research Council Turkey, 2016)Background/aim: The effects of AT 2 receptor agonist novokinin on blood pressure, eNOS, NADPH oxidase, protein arginine methyltransferases (PRMTs), and Rho kinase in hypertension were investigated. Furthermore, in isolated ... -
Endothelin-1 Lys198Asn and rs10478694 polymorphism in ischemic stroke
Aslan, Orhan; Gurger, Mehtap; Atescelik, Metin; Kara, Murat; Sen, Askin; Alataş, Ömer Doğan; Kargun, Kursat (Scientific Publishers of India, 2017)Objective: In this study, we aimed to investigate the relationship between ischemic cerebrovascular diseases and Lys198Asn and rs10478694 polymorphism of Endothelin-1 gene, a strong vasoconstrictor. Materials and Methods: ... -
Endothelin-1 Lys198Asn and rs10478694 polymorphism in ischemic stroke.
Aslan, Orhan; Gurger, Mehtap; Atescelik, Metin; Kara, Murat; Sen, Askin; Alatas, Omer Dogan; Kargun, Kursat (Scientific Publishers India, 2017)Objective: In this study, we aimed to investigate the relationship between ischemic cerebrovascular diseases and Lys198Asn and rs10478694 polymorphism of Endothelin-1 gene, a strong vasoconstrictor. Materials and Methods: ... -
ENHO gene expression and serum adropin level in rheumatoid arthritis and systemic lupus erythematosus
Yolbaş, Servet; Kara, Murat; Kalaycı, Mehmet; Yıldırım, Ahmet; Gündoğdu, Barış; Aydın, Süleyman; Koca, Suleyman Serdar (Wroclaw Medical Univ, 2018)Background. Adropin, a secreted protein, is encoded by the energy homeostasis-associated gene (ENHO). It is expressed by a variety of tissues and cells. It has been implicated in several physiological and pathological ... -
Epidemiology and Carciongenesis of Lung Cancer Part B: Lung Cancer Cancerogenesis
Kara, Murat (Bentham Science Publ, 2013)Lung cancer is one of the most common cancers and is the leading cause of cancer mortality worldwide. The development of lung cancer is a multifactorial process that involves a series of genetic and epigenetic changes. ... -
Evaluation of RELN gene polymorphism in children with autism spectrum disorder
Şahin, Nilfer; Kara, Murat; Kara, Bilge; Topal, Hatice (Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2018)Objective: With increasing frequency of autism spectrum disorder (ASD) in recent years, etiology has not yet been fully elucidated. Multiple hypotheses have been proposed to explain autism etiology including genetic, ... -
Expression changes of antioxidant, apoptotic, anti-apoptotic genes and miR-15b-34a-21-98 in over tissue by using erythromycin, quinacrine and tetracycline in non-surgical sterilization
Kara, Murat; Yumrutas, Onder; Atilgan, Remzi; Baspinar, Melike; Sapmaz, Ekrem; Kuloglu, Tuncay (Springer, 2014)In the present study, effects on expression of antioxidant, apoptotic and anti-apoptotic genes (GSR, GRX3, SOD1, RAI-NOS, HSP7, BAX, Bc1-2, CASP3 and MDH1) of substances being used in non-surgical sterilization such as ...
