Yazar "Karayakalı, Melike" için listeleme
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Crocin treatment exerts anti-inflammatory and anti-oxidative effects in liver tissue damage of pinealectomized diabetic rats
Karayakalı, Melike; Altınöz, Eyüp; Elbe, Hülya; Koca, Oğuzhan; Önal, Melike Özgül; Biçer, Yasemin; Demir, Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)Diabetes mellitus (DM) is a chronic metabolic disorder with an increasing global prevalence that leads to significant morbidity and mortality. The liver plays a vital role in glycemic regulation in physiological and ... -
Effects of pinealectomy and crocin treatment on rats with isoproterenol-induced myocardial infarction
Demir, Mehmet; Altınöz, Eyüp; Elbe, Hülya; Biçer, Yasemin; Yiğittürk, Gürkan; Karayakalı, Melike (Taylor and Francis Ltd., 2021)The present study aimed to analyze the effects of pinealectomy and crocin treatment in isoproterenol-induced myocardial damage. Seventy rats were divided into seven groups: control, sham control, pinealectomy (PNX), ... -
Neuroprotection by melatonin against acrylamide-induced brain damage in pinealectomized rats
Biçer, Yasemin; Elbe, Hülya; Karayakalı, Melike; Yigittürk, Gürkan; Yılmaz, Ümit; Cengil, Osman; Al Gburi, Mohammed Raed Abdullah; Altınöz, Eyüp (Elsevier B.V., 2022)The current study aimed to evaluate the neuroprotective effect of exogenous melatonin against acrylamide (ACR)-induced oxidative stress and inflammatory and apoptotic responses in the brain tissues in pinealectomized rats ... -
Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by alpha-naphthylthiourea
Al Gburi, Mohammed Raed Abdullah; Altınöz, Eyüp; Elbe, Hülya; Yılmaz, ümit; Yılmaz, Nesibe; Karayakalı, Melike; Önal, Melike Özgül (TAYLOR & FRANCIS LTD, 2022)We aimed to observe the possible effects of melatonin (MLT) deprivation (pinealectomy) and exogenous MLT administration on pulmonary edema induced by alpha-naphthylthiourea (ANTU), a toxic chemical agent, in rats. Seventy ... -
Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation
Öztürk, İpek; Elbe, Hülya; Biçer, Yasemin; Karayakalı, Melike; Özgul-Önal, Melike; Altınöz, Eyüp (Elsevier Ltd, 2023)Acrylamide (AA) is formed in some foods by the cooking process at high temperatures, and it could be a carcinogen in humans and rodents. The purpose of the current study was to reveal the possible protective effects of ... -
Treatment with crocin suppresses diabetic nephropathy progression via modulating TGF-β1 and oxidative stress in an experimental model of pinealectomized diabetic rats
Keelo, Rihab Mudhafar Ali Hammood; Elbe, Hülya; Biçer, Yasemin; Yiğittürk, Gürkan; Koca, Oğuzhan; Karayakalı, Melike; Acar, Derya; Altınöz, Eyüp (Elsevier, 2022)One of the most common complications of diabetes is diabetic nephropathy (DN). Uncontrolled hyperglycemia leads to histopathologic alterations in the kidney that prevent normal renal function. This study aimed to explore ...
