• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace@Muğla
  • Meslek Yüksekokulları
  • Muğla Meslek Yüksekokulu
  • Kimya ve Kimyasal İşleme Teknolojileri Bölümü Koleksiyonu
  • View Item
  •   DSpace@Muğla
  • Meslek Yüksekokulları
  • Muğla Meslek Yüksekokulu
  • Kimya ve Kimyasal İşleme Teknolojileri Bölümü Koleksiyonu
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Determination of the Effects of Bee Venom on Triple Negative Breast Cancer Cells in Vitro

Thumbnail

View/Open

Tam metin / Article (1.981Mb)

Date

2023

Author

Sevin, Sedat
Deveci Ozkan, Asuman
Tutun, Hidayet
Kıvrak, İbrahim
Turna, Özge
Güney Eskiler, Gamze

Metadata

Show full item record

Citation

Sevin S, Deveci Ozkan A, Tutun H, Kivrak I, Turna O, Guney Eskiler G. Determination of the Effects of Bee Venom on Triple Negative Breast Cancer Cells in Vitro. Chem Biodivers. 2023 Feb 19:e202201263. doi: 10.1002/cbdv.202201263. Epub ahead of print. PMID: 36806913.

Abstract

Honeybees provide multiple products such as bee venom (BV) which are used for various nutritional and medicinal purposes. BV has received great attention due to its wide range of bioactive components with potential anti-cancer effects on different cancers. Triple negative breast cancer (TNBC) is defined as an aggressive type of breast cancer and new therapeutic targets are required for its treatment. In the current literature information is varied about the composition and quantity of BV bioactive compounds as well as the origin of BV and its significance. In this context, the cytotoxic and apoptotic effects of BV with a higher rate of mellitin from Apis mellifera anatoliaca (Muğla ecotype) on MDA-MB-231 cells was evaluated, in vitro. The cytotoxic, apoptotic and morphological effects of BV were determined by WST-1, Annexin V, cell cycle analysis and Acridine Orange staining. The results showed that BV caused apoptotic cell death in TNBC cells at a lower dose (0.47 μg/mL, p<0.01). This study suggests that BV could be developed as a potential therapeutic agent for cancer treatment. However, the mechanism of BV-induced apoptosis death should be clarified at the molecular level.

Source

Chemistry and Biodiversity

URI

https://doi.org/10.1002/cbdv.202201263
https://hdl.handle.net/20.500.12809/10590

Collections

  • Kimya ve Kimyasal İşleme Teknolojileri Bölümü Koleksiyonu [65]
  • PubMed İndeksli Yayınlar Koleksiyonu [2082]
  • Scopus İndeksli Yayınlar Koleksiyonu [6219]
  • WoS İndeksli Yayınlar Koleksiyonu [6466]



DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 




| Policy | Guide | Contact |

DSpace@Muğla

by OpenAIRE
Advanced Search

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeLanguageDepartmentCategoryPublisherAccess TypeInstitution AuthorThis CollectionBy Issue DateAuthorsTitlesSubjectsTypeLanguageDepartmentCategoryPublisherAccess TypeInstitution Author

My Account

LoginRegister

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 


|| Policy || Guide|| Instruction || Library || Muğla Sıtkı Koçman University || OAI-PMH ||

Muğla Sıtkı Koçman University, Muğla, Turkey
If you find any errors in content, please contact:

Creative Commons License
Muğla Sıtkı Koçman University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@Muğla:


DSpace 6.2

tarafından İdeal DSpace hizmetleri çerçevesinde özelleştirilerek kurulmuştur.