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dc.contributor.authorDemir Pektaş, Suzan
dc.contributor.authorKara, Murat
dc.contributor.authorDoğan, Gürsoy
dc.contributor.authorPektaş, Mehmet Bilgehan
dc.contributor.authorBaloğlu, Mehmet Cengiz
dc.contributor.authorSadi, Gökhan
dc.date.accessioned2023-04-04T06:41:03Z
dc.date.available2023-04-04T06:41:03Z
dc.date.issued2023en_US
dc.identifier.citationPektaş SD, Kara M, Doğan G, Pektaş MB, Baloğlu MC, Sadi G. Differential Expression and in Silico Functional Analysis of Plasma MicroRNAs in the Pathogenesis of Non-segmental Vitiligo. Indian J Dermatol. 2022 Nov-Dec;67(6):705-714. doi: 10.4103/ijd.ijd_383_21. PMID: 36998849; PMCID: PMC10043660.en_US
dc.identifier.otherPMID: 36998849
dc.identifier.urihttps://hdl.handle.net/20.500.12809/10632
dc.description.abstractVitiligo is a disease characterized by acquired depigmentation, white macules, and patches on the skin due to the dysfunction of epidermal melanocytes. In this study, we attempt to profile the microRNA (miRNA) expression patterns and predict the potential targets, assessing the biological functions of differentially expressed miRNAs in the blood of generalized vitiligo patients. Peripheral blood samples were taken from all participants, and the expression levels of 89 identified miRNAs were analyzed with real-time quantitative polymerase chain reaction (PCR). The results indicated significant upregulation of six miRNAs and downregulation of 19 miRNAs in the plasma of vitiligo patients. The top three upregulated miRNAs were hsa-miR-451a, hsa-miR-25-3p, and hsa-miR-19a-3p, and the top three downregulated miRNAs were hsa-miR-146a-5p, hsa-miR-940, and hsa-miR-142-3p. Moreover, the miRNA expression profiles of patients with Type 3 and Type 4 phototypes were substantially different in such a way that the patients with Type 3 phototype would be more prone to the emergence of melanoma and cancer. While significant variations in the expression patterns of miRNAs in male and female vitiligo patients were demonstrated, miR-let-7i-5p, miR-19a-3p, miR-25-3p, and miR-451a were commonly upregulated, and miR-142-3p and miR-146a-5p were commonly repressed in both sexes. This study may shed light on the roles of differentially expressed miRNAs in vitiligo patients by examining the miRNA expression patterns and the combined effects of miRNA and their predicted targets.en_US
dc.item-language.isoengen_US
dc.publisherPMCen_US
dc.relation.isversionof10.4103/ijd.ijd_383_21en_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFunctional Enrichmenten_US
dc.subjectKEGG analysisen_US
dc.subjectGeneralized vitiligoen_US
dc.subjectmiRNA profileen_US
dc.titleDifferential Expression and in Silico Functional Analysis of Plasma MicroRNAs in the Pathogenesis of Non-segmental Vitiligoen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorDemir Pektaş, Suzan
dc.identifier.volume67en_US
dc.identifier.issue6en_US
dc.identifier.startpage705en_US
dc.identifier.endpage714en_US
dc.relation.journalIndian J Dermatol .en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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