Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?

Abstract

Purpose: The aim of this study was to evaluate the role of potential autoimmune mechanisms in the pathogenesis of preeclampsia by investigating the coexistence of celiac disease in patients. Material and Methods: Forty women diagnosed with preeclampsia and forty non-complicated pregnant women were enrolled in this prospective, cross-sectional, case-control study. Both groups were compared for any allergic disease symptoms, serological markers of celiac disease, total Ig A and total IgE levels. Two years later, the mothers were questioned about the presence of allergic diseases in their babies. Results: There was no statistically significant difference between the two groups for serological markers of celiac disease. However, total IgE levels of the preeclampsia group were significantly higher than that of the control group. Conclusion: In this study, we did not ascertain any coexistence of celiac disease and preeclampsia. Nevertheless, we suggest that the increased IgE levels in the preeclampsia group might be accepted as an indicator of the immune pathogenesis of preeclampsia and a potential marker for coexisting allergic diseases.