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dc.contributor.authorKarahan, G.
dc.contributor.authorKaya, H.
dc.contributor.authorErdogan, M. A.
dc.contributor.authorYigitturk, G.
dc.contributor.authorGokyayla, E.
dc.contributor.authorErbas, O.
dc.date.accessioned2020-11-20T14:43:13Z
dc.date.available2020-11-20T14:43:13Z
dc.date.issued2019
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.urihttps://doi.org/10.4149/BLL_2019_130
dc.identifier.urihttps://hdl.handle.net/20.500.12809/1163
dc.descriptionErdogan, Mumin/0000-0003-0048-444Xen_US
dc.descriptionWOS: 000493319600011en_US
dc.descriptionPubMed ID: 31663354en_US
dc.description.abstractAIM: The aim of this study was to evaluate the efficacy of trimetazidine(TMZ) after end-to-end repair in a peripheral nerve injury model. METHOD: We performed end-to-end primary repair of sciatic nerves in rats and showed TMZ's regenerative effect. For this objective 30 male Sprague Dawley albino rats were used. Surgery+water group, rats were assigned to a placebo group and were given water by oral gavage. Surgery+TMZ group, rats were given trimetazidine by oral gavage. All medications were given for 12 weeks. Motor function test was performed. Afterwards, electromyography (EMG) recording was done. Finally, blood samples were taken, the animals were euthanized andsciatic nerve was removed. RESULTS: The amplitudes of compound muscle action potential (CMAP) increased significantly in the Surgery+TMZ group when compared with the group that have been given Surgery+Water. Nerve growth factor (NGF) immunoexpression in the Schwann cell was significantly increased in the Surgery+TMZ group compared with the Surgery+Water group. Moreover, fibrosis score was reduced in the Surgery+TMZ group compared to the Surgery+Water group. CONCLUSIONS: In conclusion, we demonstrated the superiority of TMZ on nerve healing in our experimental study which was evaluated with comparative groups (Tab. 3. Fig. 2, Ref. 31).en_US
dc.item-language.isoengen_US
dc.publisherComenius Univen_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTrimetazidineen_US
dc.subjectNerve Injuryen_US
dc.subjectPrimary Repairen_US
dc.subjectNerve Regenerationen_US
dc.titleEffects of trimetazidine on nerve regeneration in a rat sciatic nerve injury modelen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Karahan, G.; Kaya, H.; Erdogan, M. A.; Yigitturk, G.; Gokyayla, E.; Erbas, O.] Bozyaka Educ & Res Hosp, Orthoped & Traumatol Dept, TR-35000 Izmir, Turkey -- [Kaya, H.] Ege Univ, Fac Med, Orthoped & Traumatol Dept, Izmir, Turkey -- [Erdogan, M. A.] Izmir Katip Celebi Univ, Fac Med, Dept Physiol, Izmir, Turkey -- [Yigitturk, G.] Mugla Univ, Fac Med Histol & Embryol, Mugla, Turkey -- [Gokyayla, E.] Ege Univ, Fac Med, Izmir, Turkey -- [Erbas, O.] Istanbul Bilim Univ, Fac Med, Dept Physiol, Istanbul, Turkeyen_US
dc.identifier.doi10.4149/BLL_2019_130
dc.identifier.volume120en_US
dc.identifier.issue10en_US
dc.identifier.startpage777en_US
dc.identifier.endpage782en_US
dc.relation.journalBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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