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dc.contributor.authorZeybek, Arife
dc.contributor.authorÖz, Necdet
dc.contributor.authorKalemci, Serdar
dc.contributor.authorEdgünüu, Tuba
dc.contributor.authorKızıltuğ, Mehmet Tuğhan
dc.contributor.authorTosun, Kürşad
dc.contributor.authorErdal, Mehmet Emin
dc.date.accessioned2020-11-20T14:43:31Z
dc.date.available2020-11-20T14:43:31Z
dc.date.issued2019
dc.identifier.issn1566-5240
dc.identifier.issn1875-5666
dc.identifier.urihttps://doi.org/10.2174/1566524019666190314113800
dc.identifier.urihttps://hdl.handle.net/20.500.12809/1198
dc.description0000-0003-3656-9947en_US
dc.descriptionWOS: 000470852800007en_US
dc.descriptionPubMed ID: 30868951en_US
dc.description.abstractBackground: We aimed at exploring biological functions of differentially expressed miRNAs during carcinogenesis, to identify miRNAs dysegulations involved in DNA repair mechanisms, and to evaluate potential of miRNAs as prognostic and diagnostic biomarkers for early lung adenocarcinomas (LAC). Methods: We obtained 21 LAC and paired adjacent normal formalin-fixed, paraffin-embedded lung tissues from patients who underwent curative resection for stage I LAC. We compared expression levels of eight miRNAs involved in the DNA repair mechanism between LAC and adjacent tissues. Results: Expressions of Hsa-miR-9-5p, hsa-miR-24-3p, hsa-miR-125a-3p, hsa-miR-125b-5p, hsa-miR-155-5p, and hsa-let-7a-5p were significantly up-regulated in stage I LAC tissues compared with those in the adjacent tissues. In addition, expressions of hsa-mir-9-5p, hsa-mir-24-3p, hsa-mir-125a-3p, hsa-mir-125b-5p, and hsa-mir-155-5p were significantly up-regulated in stage la LAC tissues, whereas expressions of hsa-mir125a-3p and hsa-mir-125b-5p were significantly up-regulated in stage lb LAC tissues. Receiver operating characteristic (ROC) analysis revealed that AUROC of hsa-mir-125b-5p was 0.875 (P < 0.001). Conclusion: Expression of hsa-mir-125b-5p could be used to distinguish LAC from adjacent tissues. Our result suggests that hsa-mir125b-5p can be a prognostic and diagnostic biomarker for LAC.en_US
dc.item-language.isoengen_US
dc.publisherBentham Science Publ Ltden_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarcinomaen_US
dc.subjectNon-Small Cell Lung Canceren_US
dc.subjectAdenocarcinomaen_US
dc.subjectMicro RNAen_US
dc.subjectMir-125ben_US
dc.subjectBiomarkersen_US
dc.titleDiagnostic Value of MiR-125b as a Potential Biomarker for Stage I Lung Adenocarcinomaen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorZeybek, Arife
dc.contributor.institutionauthorEdgünüu, Tuba
dc.identifier.doi10.2174/1566524019666190314113800
dc.identifier.volume19en_US
dc.identifier.issue3en_US
dc.identifier.startpage216en_US
dc.identifier.endpage227en_US
dc.relation.journalCurrent Molecular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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