Comparison of reference systems in the assessment of age-related serum immunoglobulin levels in pediatric patients
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Tarih
2019Yazar
Kulhas Celik, IlknurCivelek, Ersoy
Metin, Ayse
Ginis, Tayfur
Toyran, Muge
Dibek Misirlioglu, Emine
Kocabaş, Can Naci
Üst veri
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Background/aim: Ig level assessment is frequently used in the diagnosis and follow-up of immunodeficiency, as well as in studies investigating the prevalence of low serum Ig level in specific diseases. Material and methods: Patients who underwent Ig testing in the inpatient and outpatient clinics of our hospital in the years 2010-2016 were included. The Ig levels of the patients were assessed separately according to two reference systems commonly used in Turkey and another reference system used in the USA. Results: A total of 20,138 patients (57.6% male) were included in the study. "lhe median age of the patients was 55.7 months (interquartile range: 23.1-96.7). According to the reference intervals determined by Tezcan et al., 30.6% of the patients were deficient in one or more Ig values. This rate was 4 times higher than those based on the reference intervals determined by Aksu et al. (7.7%) and those in the Nelson Textbook of Pediatrics (6.8%). We also determined that the frequency of low Ig levels with three reference systems. Conclusion: In this study, we found that the rates of low Ig level in a group of pediatric patients differed significantly when evaluated using three different reference systems for age-related serum Ig levels
Kaynak
Turkish Journal of Medical SciencesCilt
49Sayı
1Bağlantı
https://doi.org/10.3906/sag-1805-220https://app.trdizin.gov.tr//makale/TXpNMU56WTVPUT09
https://hdl.handle.net/20.500.12809/1241