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dc.contributor.authorGencer, Erkan
dc.contributor.authorDoğan, Volkan
dc.contributor.authorOzturk, Mujgan Tek
dc.contributor.authorNadir, Aydin
dc.contributor.authorMusmul, Ahmet
dc.contributor.authorCavusoglu, Yuksel
dc.date.accessioned2020-11-20T14:53:24Z
dc.date.available2020-11-20T14:53:24Z
dc.date.issued2017
dc.identifier.issn1074-2484
dc.identifier.issn1940-4034
dc.identifier.urihttps://doi.org/10.1177/1074248416657612
dc.identifier.urihttps://hdl.handle.net/20.500.12809/2021
dc.descriptionWOS: 000393947600007en_US
dc.descriptionPubMed ID: 27390145en_US
dc.description.abstractBackground: Cardiac troponins (cTn) are reliable and the most sensitive biomarker in the setting of acute decompensated heart failure (ADHF). Acute decompensated heart failure is usually associated with worsening chronic heart failure, and it may be caused by ongoing minor myocardial cell damage that may occur without any reported precipitating factors. Methods: We compared the short-term effect of levosimendan (LEV), dobutamine (DOB), and vasodilator treatment (nitroglycerin [NTG]) on myocardial injury with hemodynamic, neurohumoral, and inflammatory indicators. One hundred twenty-two patients with a mean age of 66 +/- 9 years were treated with LEV (n = 40), DOB (n = 42), and NTG (n = 40) and examined retrospectively. Blood samples (cTnI, N-terminal probrain natriuretic peptide [NT-proBNP], highly sensitive C-reactive protein [HsCRP], and others), left ventricular ejection fraction (LVEF), systolic pulmonary artery pressure (sPAP), and 6-minute walk distance (6MWD) were compared before and after treatment. Results: At admission, detectable levels of cTnI were observed in 53% of patients (>= 0.05 ng/mL). Serial changes in the mean cTnI levels were not significantly different between the groups (LEV 0.04 +/- 0.01 to 0.03 +/- 0.01 ng/mL; DOB 0.145 +/- 0.08 to 0.08 +/- 0.03 ng/mL; NTG 0.1 +/- 0.03 to 0.09 +/- 0.02 ng/mL; overall P = .859). Favourable effects on the NT-proBNP, sPAP values, LVEF, 6MWD, and HsCRP were observed overall, especially in the LEV groups. Conclusion: Beneficial effects of short-term use of LEV, DOB, and NTG on ongoing myocardial injury were demonstrated. These findings can be attributed to the anti-ischemic properties as well as the hemodynamic, neurohumoral, and functional benefits from the positive inotropes, especially LEV, in patients with ADHF.en_US
dc.item-language.isoengen_US
dc.publisherSage Publications Incen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeart Failureen_US
dc.subjectLevosimendanen_US
dc.subjectDobutamineen_US
dc.subjectTroponinen_US
dc.titleComparison of the Effects of Levosimendan Dobutamine and Vasodilator Therapy on Ongoing Myocardial Injury in Acute Decompensated Heart Failureen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorDoğan, Volkan
dc.identifier.doi10.1177/1074248416657612
dc.identifier.volume22en_US
dc.identifier.issue2en_US
dc.identifier.startpage153en_US
dc.identifier.endpage158en_US
dc.relation.journalJournal of Cardiovascular Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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