Yazar "MÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
-
Effects of pinealectomy and crocin treatment on rats with isoproterenol-induced myocardial infarction
Demir, Mehmet; Altınöz, Eyüp; Elbe, Hülya; Biçer, Yasemin; Yiğittürk, Gürkan; Karayakalı, Melike (Taylor and Francis Ltd., 2021)The present study aimed to analyze the effects of pinealectomy and crocin treatment in isoproterenol-induced myocardial damage. Seventy rats were divided into seven groups: control, sham control, pinealectomy (PNX), ... -
Effects of Theophylline with Methylprednisolone Combination Therapy on Biomechanics and Histopathology in Diaphragm Muscles of Rats
Yüzkat, Nureddin; Katı, İsmail; Işık, Yasemin; Kavak, Servet; Göktaş, Uğur; Cengiz, Nurettin (Springer/Plenum Publishers, 2016)The purpose of this study was to investigate the effects of theophylline and methylprednisolone on the mechanical response and histopathology of hemidiaphragm muscle in rats. In the current study, we aimed to investigate ... -
Effects of varenicline on lung tissue in the animal model
Ermis, Hilal; Parlakpinar, Hakan; Elbe, Hülya; Vardi, Nigar; Polat, Alaaddin; Gulbas, Gazi (Soc Brasileira Pneumologia Tisiologia, 2020)Objective: This study aimed to investigate acute and chronic effects of varenicline on lung tissue in an experimental study. Methods: A total of 34 rats were randomly allocated into study (varenicline) and control groups. ... -
The efficacy of Aesculus hippocastanum seeds on diabetic nephropathy in a streptozotocin-induced diabetic rat model
Elmas, Onur; Erbaş, Oytun; Yiğittürk, Gürkan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Cytokines, such as transforming growth factor (TGF)-beta 1, and increased oxidative stress are considered to be responsible for the development of diabetic nephropathy. We hypothesized that Aesculus hippocastanum (AH) seeds ... -
Endotoxin exposure and puberty in female rats: the role of nitric oxide and caspase-1 inhibition in neonates
Özgöçer, Tuba; Yıldız, Sedat; Elbe, Hülya; Vardı, Nigar (Canadian Science Publishing, Nrc Research Press, 2015)Bacterial toxins are widespread in the environment as well as in the digestive system of humans and animals. Toxin from Gram-negative bacteria (endotoxin or lipopolysaccharide; LPS) has a life-long programming effect on ... -
Evaluation of the neuroprotective effects of ozone in an experimental spine injury model
Gürkan, Gökhan; Sayın, Murat; Kızmazoğlu, Ceren; Erdoğan, Mumin Alper; Yigittürk, Gürkan; Yılmaz, Huriye Erbak; Yüceer, Nurullah (Amer Assoc Neurological Surgeons, 2020)OBJECTIVE The pathophysiology of spine injury consists of primary and secondary damage mechanisms. The vast majority of treatments aim to prevent or at least stop the progression of secondary neurotoxic events during the ... -
An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment
Taşkın, Banu; Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Alper, Sibel; Erbaş, Oytun (Hindawi, 2021)Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. ... -
Exploration of Potential miRNA Biomarkers and Prediction for Ovarian Cancer Using Artificial Intelligence
Hamidi, Farzaneh; Gilani, Neda; Belaghi, Reza Arabi; Sarbakhsh, Parvin; Edgünlü, Tuba; Santaguida, Pasqualina (MedGen, 2021)Ovarian cancer is the second most dangerous gynecologic cancer with a high mortality rate. The classification of gene expression data from high-dimensional and small-sample gene expression data is a challenging task. The ... -
Ghrelin may reduce radiation-induced mucositis and anorexia in head-neck cancer
Güney, Yıldız; Türkcü Özel, Ümmühani; Hiçsönmez, Ayşe; Andrieu, Mettem Nalcal; Kurtman, Cengiz (Churchill Livingstone, 2007)Body weight toss is common in cancer patients, and is often associated with poor prognosis, it greatly impairs quality of life (QOL). Radiation therapy (RT) is used in head and neck cancers (HNC) either as a primary treatment ... -
GPR30 Gene Polymorphisms Are Associated with Gynecomastia Risk in Adolescents
Korkmaz, Hüseyin Anıl; Edgünlü, Tuba; Eren, Erdal; Demir, Korcan; Çakır, Esra Deniz Papatya; Çelik, Sevim Karakaş; Özkan, Behzat (Karger, 2015)Aim: The G protein-coupled receptor, GPR30, which is a third estrogen receptor, has been shown to mediate estrogenic effects on the essential features of human breast cancer cells. The aim of this study was to evaluate the ... -
The Healing Effect of Digoxin on Peripheral Nerve Damage and Its Relation to IL-17/IL-10
Gürkan, Gökhan; Erdoğan, Mümin Alper; Karahan, Gökhan; Kaya, Hüseyin; Yiğittürk, Gürkan (Turkish Neurosurgical Society, 2023)AIM: To demonstrate the curative effect of digoxin on peripheral nerve damage with its anti-inflammatory role on interleukin (IL)-17. MATERIAL and METHODS: The study was conducted with 30 male Sprague Dawley albino mature ... -
Homozygous Ala65Pro Mutation with V89L Polymorphism in SRD5A2 Deficiency
Eren, Erdal; Edgünlü, Tuba; Asut, Emre; Çelik, Sevim Karakaş (Galenos Yayincilik, 2016)Objective: Deficiency of steroid 5-alpha reductase type 2 (5 alpha RD2) is a rare autosomal recessive disorder caused by mutations in the SRD5A2 gene. A defect in the 5-alpha reductase enzyme, which ensures conversion of ... -
Hydroquinidine displays a significant anticarcinogenic activity in breast and ovarian cancer cells via inhibiting cell-cycle and stimulating apoptosis
Yavuz, Mervenur; Demircan, Turan; Şahin, Betül; Baykal, Ahmet Tarık (TUBITAK, 2023)Breast and ovarian cancers are women’s most commonly diagnosed cancers. Seeking an efficient anticarcinogenic compound is still a top priority regarding the aggressiveness of these cancers and the limited benefit of current ... -
Identifying Potential miRNA Biomarkers for Gastric Cancer Diagnosis Using Machine Learning Variable Selection Approach
Gialini, Neda; Belaghi, Reza Arabi; Aftabi, Younes; Faramarzi, Elnaz; Edgünlü, Tuba (Frontiers Media S.A., 2022)Aim: This study aimed to accurately identification of potential miRNAs for gastric cancer (GC) diagnosis at the early stages of the disease. Methods: We used GSE106817 data with 2,566 miRNAs to train the machine learning ... -
Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats
Koyu, Ahmet; Gökalp, Osman; Gümral, Nurhan; Öktem, Faruk; Karahan, Nermin; Yılmaz, Nigar; Saygın, Mustafa (Sage Publications Inc, 2016)This study investigates the preventive effect of caffeic acid phenethyl ester (CAPE) on pancreatic damage induced by vancomycin (VCM) in rats. Rats were equally divided into three groups: group I (control), group II (only ... -
The impact of gender and academic achievement on the violation of academic integrity for medical faculty students, a descriptive cross-sectional survey study
Özcan, Müesser; Yeniçeri, Neşe; Çekiç, Edip Güvenç (Bmc, 2019)Purpose: The aim of this study is to determine the characteristics of medical faculty students about violations of academic integrity. Method: From the whole population of the 572 students of the Mugla Sitki Kocman University ... -
Important milestones for cancer at the Nobel prize
Tanrıverdi, Özgür; Tasar, Muhammed; Yılmaz, Mustafa; Durak, Melih Furkan; Sezer, Selin Beyza; Demir Küreci, Hatice; Özcan, Müesser (Wolters Kluwer Medknow Publications, 2020)The Nobel Prize, which is awarded annually, is open to everyone, regardless of nationality, race, belief or ideology, and winners are announced in October. We evaluated the history of the Nobel prizes for awards that have ... -
In Vitro Effects of Propofol on Cytotoxic, Apoptotic and PI3K-Akt Signaling Pathway Genes on Brain Cancer Cells
Gökdoğan Edgünlü, Tuba; Avcı, Cigir Biray; Özateş, Neslihan Pınar; Göker Bağca, Bakiye; Karakaş Çelik, Sevim; Bölük, Aydın; Uğur, Bakiye (Bentham Science, 2021)Aim: It was aimed to determine the cytotoxic and apoptotic effect of propofol on glioma cells. Background: Propofol [2,6-diisopropylphenol] is a commonly used intravenous anesthetic. Propofol is known to have a mechanism ... -
Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis
Haqi Ballur, Arwa Fadil; Altınöz, Eyüp; Yiğittürk, Gürkan; Özgül Önal, Melike; Elbe, Hülya (Springer, 2022)Gout is an inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints or soft tissue. MSU crystals are potent inflammation inducers. Melatonin (MLT) is a powerful endogenous ... -
Integrative Analysis of Axolotl Gene Expression Data from Regenerative and Wound Healing Limb Tissues
Sibai, Mustafa; Parlayan, Cüneyd; Tuğlu, Pelin; Özturk, Gürkan; Demircan, Turan (Nature Research, 2019)Axolotl (Ambystoma mexicanum) is a urodele amphibian endowed with remarkable regenerative capacities manifested in scarless wound healing and restoration of amputated limbs, which makes it a powerful experimental model for ...