Yazar "MÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
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Investigation of effects of short-term exposure to 50HZ magnetic field on central, peripheral, and autonomic nervous systems in rats
Elmas, Onur; Çömlekçi, Selçuk (Wiley-Blackwell, 2015)Although a large number of exposure studies have been carried out to investigate possible detrimental effects of a power-line frequency magnetic field (PF-MF; 50-60Hz) on living organisms, there is no consensus in reported ... -
The investigation of therapeutic potential of oxytocin and liraglutide on vincristine-induced neuropathy in rats
Erdogan, Mumin A.; Taskiran, Emin; Yiğittürk, Gürkan; Erbas, Oytun; Taskiran, Dilek (Wiley, 2020)The aim of this study was to assess the therapeutic potential of oxytocin and liraglutide (LIR), a GLP-1 analogue, in a rat model of vincristine-induced neuropathy. Rats were injected with vincristine (VCR) at a dose of 4 ... -
Leptin Accelerates Endothelial Wound Healing: Role of Endothelial Nitric Oxide Synthase Expression
Yiğittürk, Gürkan; Önal, Melike Özgül; Subaşı, Ekin; Doğan, Beyza; Türkmenoğlu, Melih; Kaplan, Merve; Yaşar, Volkan; Elbe, Hülya; Öztürk, Feral; 0000-0002-5315-253X (Turkish Society of Cardiology, 2022)Background: The endothelium is crucial for the control of vascular homeostasis and plays a role in angiogenesis. Leptin, a protein released mainly by adipose tissue, plays a key role in the regulation of energy balance and ... -
Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress
Altınöz, Eyüp; Öner, Zulal; Elbe, Hülya; Üremiş, Nuray; Üremiş, Muhammed (Taylor and Francis Ltd., 2021)The aim of the present study was to investigate the therapeutic and protective effects of linalool against doxorubicin (DOX)-induced kidney injury. Forty-eight Wistar rats were divided into 8 groups as follows; Control, ... -
Losartan ameliorates ovarian ischaemia/reperfusion injury in rats: an experimental study
Hortu, Ismet; Ilgen, Orkun; Sahin, Cagdas; Akdemir, Ali; Yiğittürk, Gürkan; Erbas, Oytun (Taylor & Francis Inc, 2020)This study aimed to investigate the protective and antioxidant role of losartan in ovarian ischaemia and ischaemia/reperfusion injury in an experimental ovarian torsion model. Thirty adult female rats were used. Rats were ... -
m 6 A Pathway Regulators Are Frequently Mutated in Breast Invasive Carcinoma and May Play an Important Role in Disease Pathogenesis
Demircan, Turan; Yavuz, Mervenur; Akgül, Sıddıka (Mary Ann Liebert, 2021)Breast invasive carcinoma (BIC) is one of the most commonly observed and the deadliest cancer among women. Studies examining the role of epigenetics and regulation of gene expression stand to make important strides in ... -
Methotrexate-Induced Nephrotoxicity in Rats: Protective Effect of Mistletoe (Viscum album L.) Extract
Çetin, Esin Sakallı; Tetiker, Hasan; Çelik, Özgür İlhan; Yılmaz, Nigar; Ciğerci, İbrahim Hakkı (Karger, 2017)Background: The protective effect of mistletoe extract (Helixor((R)), HLX) against methotrexate (MTX)-induced acute oxidative stress and nephrotoxicity in rats was evaluated by histological and biochemical methods as well ... -
Microbiome and Longevity: High Abundance of Longevity-Linked Muribaculaceae in the Gut of the Long-Living RodentSpalax leucodon
Sibai, Mustafa; Altuntaş, Ebru; Yıldırım, Berna; Öztürk, Gürkan; Yıldırım, Süleyman; Demircan, Turan (Mary Ann Liebert, Inc, 2020)With a world population living longer as well as marked disparities in life expectancy, understanding the determinants of longevity is one of the priority research agendas in 21st century life sciences. To this end, the ... -
miR-181a-5p is a potential candidate epigenetic biomarker in multiple sclerosis
Edgünlü, Tuba; Görücü Yılmaz, Şenay; Emre, Ufuk; Taşdelen, Bahar; Kuru, Oktay; Kutlu, Gülnihal; Erdal, Mehmet Emin (NLM (Medline), 2022)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal degeneration. Abnormal expression of microRNAs (miRNAs) plays an important role in MS ... -
Mistletoe (Viscum album L.) extract attenuates ıtraconazole-ınduced acute oxidative stress and hepatocellular ınjury in rats
Çetin Sakallı, Esin; Sözen, Hamdi; Çelik, Özgür İlhan; Ciğerci, İbrahim Hakkı; Yılmaz, Nigar (UNIV KARACHI, 2023)In the current study, the protective effect of a mistletoe extract (Helixor (R), HLX) on Itraconazole (ITZ)-induced hepatocellular injury and acute oxidative stress in rats was aimed to be investigated by histological, ... -
Morphometric assessment of important landmarks on skull intended for Vidian nerve surgery
Ucerler, Hulya; Aktan Ikiz, Zuhre Asli; Yörük, Mustafa Deniz; Boduc, Erengul; Ozturk, Lokman (Springer, 2020)Purpose: The aim of our study was to determine guide parameters for clinicians by morphometric assessment of important landmarks on cranium intended for Vidian nerve surgery. Methods: For the study, 23 half-skull bases, ... -
MRI-based detailed evaluation of the anatomy of the human coccyx among Turkish adults
Tetiker, Hasan; Koşar, Mehmet İlkay; Çullu, Neşat; Canbek, Umut; Otağ, I.; Taştemur, Y. (Medknow Publications & Media Pvt Ltd, 2017)Aim: The human coccyx varies considerably in shape and size. The objective of this study was to investigate the morphology and morphometry of the coccyx on pelvic magnetic resonance imaging in asymptomatic individuals among ... -
Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats
Erdoğan, Mümin Alper; Yiğittürk, Gürkan; Erbaş, Oytun; Taşkıran, Dilek (TAYLOR & FRANCIS INC, 2021)Aim: Although the most common age-related neurodegenerative disease defined by memory loss is Alzheimer's disease (AD), only symptomatic therapies are present. A complex pathway for the AD pathogenesis that includes an ... -
A new strategy to achieve high antimicrobial activity: green synthesised silver nanoparticle formulations with Galium aparine and Helichrysum arenarium
Özdemir, Çilem; Gencer, Merve; Çoksu, İrem; Özbek, Tülin; Derman, Serap (SCIENDO, 2023)Silver nanoparticles (AgNPs), which have recently gained attention due to their antimicrobial activity, can also be produced by green synthesis. The aims of this study were to (i) characterise green synthesized AgNPs using ... -
Novel Fructose-1,6-bisphosphatase Gene Mutation in Two Siblings
Eren, Erdal; Edgünlü, Tuba; Abuhandan, Mahmut; Yetkin, İlhan (Mary Ann Liebert, Inc, 2013)Fructose-1,6-bisphosphatase (FBPase) deficiency is an autosomal, recessively inherited disease that progresses with severe hypoglycemia, and metabolic attacks result in a defect in gluconeogenesis. If not appropriately ... -
Oxytocin and cabergoline alleviate ovarian hyperstimulation syndrome (OHSS) by suppressing vascular endothelial growth factor (VEGF) in an experimental model
Hortu, Ismet; Karadadas, Elif; Ozceltik, Gokay; Tavmergen, Erol; Tavmergen Goker, Ege Nazan; Erbas, Oytun; Yiğittürk, Gürkan (Springer Heidelberg, 2020)Purpose Ovarian hyperstimulation syndrome (OHSS) is a life-threatening complication of ovarian stimulation in reproductive medicine. Here, we aimed to investigate the role of oxytocin (OT) and cabergoline in the prevention ... -
Patient's companions as a vulnerable group in Turkish hospitals: A descriptive study
Akpinar, Aslihan; Özcan, Müesser; Ülker Toygar, Deniz (Blackwell Publishing Ltd, 2020)Background: In Turkish hospitals, in addition to health care professionals, there are people who are also a significant part of the health care services; even though they are not professionals. In Turkey, these people are ... -
Physiological parameters as a tool in the diagnosis of fibromyalgia syndrome in females: A preliminary study
Elmas, Onur; Yildiz, Sedat; Bilgin, Suleyman; Demirci, Seden; Comlekci, Selcuk; Koyuncuoglu, Hasan Rifat; Bilgin, Gurkan (Pergamon-Elsevier Science Ltd, 2016)Aims: Although fibromyalgia (FM) syndrome is associated with many symptoms, there is as yet no specific finding or laboratory test diagnostic of this syndrome. The physical examination and laboratory tests may be helpful ... -
The potential effects of anticonvulsant drugs on neuropeptides and neurotrophins in pentylenetetrazol kindled seizures in the rat
Tekgul, Hasan; Simsek, Erdem; Erdogan, Mumin Alper; Yiğittürk, Gürkan; Erbas, Oytun; Taskiran, Dilek (Taylor & Francis Ltd, 2020)Purpose: Neuropeptides and neurotrophic factors are thought to be involved in epileptogenesis. This study aims to investigate the potential effects of anticonvulsant drugs on neuropeptides (galanin and neuropeptide Y) and ... -
Preclinical Molecular Signatures of Spinal Cord Functional Restoration: Optimizing the Metamorphic Axolotl (Ambystoma mexicanum) Model in Regenerative Medicine
Demircan, Turan; Hacibektasogu, Harbiye; Sibai, Mustafa; Fescioglu, Ece Cana; Altuntaş, Ebru; Ozturk, Gurkan; Süzek, Barış Ethem (Mary Ann Liebert, Inc, 2020)Regenerative medicine offers hope for patients with diseases of the central and peripheral nervous system. Urodele amphibians such as axolotl display an exceptional regenerative capacity and are considered as essential ...