Yazar "Kara, Murat" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
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The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells
Bayram, D.; Çetin, Esin Sakallı; Kara, Murat; Özgöçmen, M.; Candan, I. A. (Sage Publications Ltd, 2017)Background: Silibinin is a bioactive flavonolignan extracted from milk thistle, known as Silybum marianum. Silibinin exerts strong antiproliferative, proapoptotic, and anti-inflammatory effects. Many studies have shown ... -
Application of talcum powder, trichloroacetic acid and silver nitrate in female rats for non-surgical sterilization: evaluation of the apoptotic pathway mRNA and miRNA genes
Yumrutaş, Önder; Kara, Murat; Atılgan, Remzi; Kavak, Salih Burçin; Bozgeyik, İbrahim; Sapmaz, Ekrem (Wiley, 2015)There are several methods used for non-surgical sterilization in birth control including quinacrine, trichloroacetic acid (TCA), erythromycin, tetracycline, silver nitrate and talcum powder. Among these, talcum powder, TCA ... -
Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis
Kara, Murat; Yolbaş, Servet; Şahin, Cem; Koca, Süleyman Serdar (Aves, 2017)Objective: Sirtuins (SIRTs) play a prominent role in metabolism, apoptosis, aging, inflammation, and epigenetics. Inflammation, apoptosis, and epigenetics are pathogenic issues in rheumatoid arthritis (RA). This study aimed ... -
Chromosomal Translocation t (10; 19) (q11.2; q13.4) in an Infertile Male
Kara, Murat; Sen, Askin; Cetin, Esin Sakalli; Kargun, Kursat (Aves, 2014)Chromosomal rearrangements are usually associated with male factor infertility. We report here a 34-year-old man suffering from primary infertility for 15 years. The cytogenetic analysis and investigation of Y-chromosome ... -
Determination of the effects on learning and memory performance and related gene expressions of clothianidin in rat models
Özdemir, Hasan Hüseyin; Kara, Murat; Yumrutaş, Önder; Üçkardeş, Fatih; Eraslan, Ersen; Demir, Caner F.; Bal, Ramazan (Springer, 2014)Clothianidin (CLO) is one of the pesticides used to protect against insects, and its potential toxic effects on cognitive functions are not clearly known. This study aims to evaluate the possible effects of dose-dependent ... -
Differential Expression and in Silico Functional Analysis of Plasma MicroRNAs in the Pathogenesis of Non-segmental Vitiligo
Demir Pektaş, Suzan; Kara, Murat; Doğan, Gürsoy; Pektaş, Mehmet Bilgehan; Baloğlu, Mehmet Cengiz; Sadi, Gökhan (PMC, 2023)Vitiligo is a disease characterized by acquired depigmentation, white macules, and patches on the skin due to the dysfunction of epidermal melanocytes. In this study, we attempt to profile the microRNA (miRNA) expression ... -
Differential Expression of MicroRNAs in Chronic Obstructive Pulmonary Disease
Kara, Murat; Kirkil, Gamze; Kalemci, Serdar (Wroclaw Medical Univ, 2016)Background. This study aimed to investigate the associations of miRNA with COPD patients. Objectives. Chronic obstructive pulmonary disease (COPD) is characterized by progressive and largely irreversible airflow limitation. ... -
Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma
Kara, Murat; Yumrutaş, Önder; Özcan, Önder; Çelik, Özgür İlhan; Bozgeyik, Esra; Bozgeyik, İbrahim; Taşdemir, Şener (Elsevier Science Bv, 2015)Colorectal cancer is one of the frequently seen malignancies in the world. To date, several oncogenes and tumor suppressor genes have been identified and linked to colorectal cancer pathogenesis. Although recent advances ... -
Ectodermal dysplasia-skin fragility syndrome with a new mutation
Alataş, Emine Tuğba; Kara, Asude; Kara, Murat; Doğan, Gürsoy; Baysal, Onur (Wolters Kluwer Medknow Publications, 2017) -
The effects of novokinin, an AT2 agonist, on blood pressure, vascular responses, and levels of ADMA, NADPH oxidase, and Rho kinase in hypertension induced by NOS inhibition and salt
Mutlu, Emre; Ilhan, Selcuk; Onat, Elif; Kara, Murat; Sahna, Engin (Tubitak Scientific & Technical Research Council Turkey, 2016)Background/aim: The effects of AT 2 receptor agonist novokinin on blood pressure, eNOS, NADPH oxidase, protein arginine methyltransferases (PRMTs), and Rho kinase in hypertension were investigated. Furthermore, in isolated ... -
ENHO gene expression and serum adropin level in rheumatoid arthritis and systemic lupus erythematosus
Yolbaş, Servet; Kara, Murat; Kalaycı, Mehmet; Yıldırım, Ahmet; Gündoğdu, Barış; Aydın, Süleyman; Koca, Suleyman Serdar (Wroclaw Medical Univ, 2018)Background. Adropin, a secreted protein, is encoded by the energy homeostasis-associated gene (ENHO). It is expressed by a variety of tissues and cells. It has been implicated in several physiological and pathological ... -
Expression changes of antioxidant, apoptotic, anti-apoptotic genes and miR-15b-34a-21-98 in over tissue by using erythromycin, quinacrine and tetracycline in non-surgical sterilization
Kara, Murat; Yumrutas, Onder; Atilgan, Remzi; Baspinar, Melike; Sapmaz, Ekrem; Kuloglu, Tuncay (Springer, 2014)In the present study, effects on expression of antioxidant, apoptotic and anti-apoptotic genes (GSR, GRX3, SOD1, RAI-NOS, HSP7, BAX, Bc1-2, CASP3 and MDH1) of substances being used in non-surgical sterilization such as ... -
The IL-33 gene is related to increased susceptibility to systemic sclerosis
Koca, Süleyman Serdar; Pehlivan, Yavuz; Kara, Murat; Alibaz-Öner, Fatma; Öztuzcu, Serdar; Yılmaz, Neslihan; Onat, Ahmet Mesut (Springer Heidelberg, 2016)Systemic sclerosis (SSc) is a chronic inflammatory disease characterized by widespread fibrosis of the skin and several visceral organs. The pro-fibrotic potential of interleukin (IL)-33 has been demonstrated by in both ... -
Influence of omega-3 fatty acid on orthodontic tooth movement in rats: A biochemical, histological, immunohistochemical and gene expression study
Öğrenim, Gözde; Cesur, Mine G.; Önal, Tuna; Kara, Murat; Şirin, Fevziye B.; Yalçın, Gizem D.; İnan, Sevinç (Wiley, 2019)Structured Abstract Objective The aim of this study was to investigate the effects of omega-3 fatty acids on orthodontic tooth movement. Setting and Sample Population For this study, 56 12-week-old adult male Wistar albino ... -
Insecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model
Kara, Murat; Yumrutaş, Önder; Demir, Caner F.; Özdemir, Hasan Hüseyin; Bozgeyik, İbrahim; Coşkun, Salih; Bal, Ramazan (Wiley, 2015)The potential toxic effects of several pesticides, including imidacloprid on non-target organisms have not been clearly established. Also, the chronic effects of non-toxic doses on cognitive function in mammals are unknown. ... -
Lack of association between increased mitochondrial DNA(4977) deletion and ATP levels of sputum cells from chronic obstructive pulmonary disease patients versus healthy smokers
Karimova, A.; Oltulu, Y. M.; Azaklı, H.; Kara, Murat; Ustek, D.; Tutluoglu, B.; Onaran, I. (Taylor & Francis Ltd, 2017)In this study we looked at smokers with and without chronic obstructive pulmonary disease (COPD) patients in order to evaluate the incidence of 4977 base pair (bp) mtDNA (mtDNA(4977)) deletion and mtDNA copy number in ... -
Low prevalence of obesity in Behçet's disease is associated with high obestatin level
Koca, Süleyman Serdar; Kara, Murat; Özgen, Metin; Dayanan, Ramazan; Demir, Caner Feyzi; Aksoy, Kader; Işık, Ahmet (2017)Objective: Chronic inflammatory diseases are associated with altered body composition. Ghrelin has anti-inflammatory effects, and its level is altered in obesity and inflammatory diseases. The aim of the study was to ... -
Methylation of cation-chloride cotransporters NKCC1 and KCC2 in patients with juvenile myoclonic epilepsy
Genç, Fatma; Kara, Murat; Ünal, Yasemin; Küçükseymen, Elif Uygur; Gömceli, Yasemin Biçer; Kaynar, Taner; Kutlu, Gülnihal (Springer-Verlag Italia Srl, 2019)The etiology of juvenile myoclonic epilepsy (JME) is still unknown and the process of elaboration of multiple genetic mechanisms is ongoing. The aim of this study was to investigate the potential role of NKCC1 (SCL12A2) ... -
THE METHYLATION STATUS OF NKCC1 AND KCC2 IN THE PATIENTS WITH REFRACTORY TEMPORAL LOBE EPILEPSY
Ünal, Yasemin; Kara, Murat; Genç, Fatma; Aslan Öztürk, Dilek; Biçer Gömceli, Yasemin; Kaynar, Toner; Kutlu, Gülnihal (Literatura Medica, 2019)Purpose - Methylation is a key epigenetic modification of DNA and regarding its impact on epilepsy, it is argued that "DNA methylation may play an important role in seizure susceptibility and maintenance of the disorder". ... -
MTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations
Ozcan, Onder; Kara, Murat; Yumrutas, Onder; Bozgeyik, Esra; Bozgeyik, Ibrahim; Celik, Ozgur Ilhan (Sage Publications Ltd, 2016)Deregulated microRNA (miRNA) expression has been shown to be involved in the pathogenesis of several types of cancers including colorectal cancer (CRC). Thus, determining miRNA targets of genes that play critical role in ...