Yazar "MÜ, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
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Adjuvant composite cold atmospheric plasma therapy increases antitumoral effect of doxorubicin hydrochloride
Baysal, Ömür; Kniazeva, Volha; Tzerkovsky, Dzmitry; Kornev, Alexander; Kostevitch, Serhei (PMC, 2023)Introduction: Cancer is a global health concern, with a significant impact on mortality rates. Despite advancements in targeted antitumor drugs, the development of new therapies remains challenging due to high costs and ... -
Antimicrobial screening to molecular docking of newly synthesized ferrocenyl-substituted pyrazole
Sharma, Shashi; Tuli, Hardeep Singh; Varol, Mehmet (QASSIM UNIV, 2022)Objective: Microbial diseases are snowballing at an alarming proportion. Therefore, the intent of this study was to inspect the antimicrobial action of ferrocenyl-substituted pyrazole against various human pathogenic ... -
Antioxidant, Cytotoxicity, Apoptotic Properties of Extracts of Andricus sternlichti galls and Their Phenolic Characterisation by HPLC
Kılınçarslan Aksoy, Özge; Seçme, Mücahit; Mammadov, Ramazan (John Wiley and Sons Inc, 2022)Quercus L. galls have been used in Western and Eastern cultures for various diseases in traditional medicine. Galls are also used in the East for many purposes, including consumption as food, commercial inks, leather ... -
Comprehensive Profiling of Genomic and Transcriptomic Differences between Risk Groups of Lung Adenocarcinoma and Lung Squamous Cell Carcinoma
Zengin, Talip; Önal Süzek, Tuğba (MDPI, 2021)Lung cancer is the second most frequently diagnosed cancer type and responsible for the highest number of cancer deaths worldwide. Lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) are subtypes of ... -
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies
Tuli, Hardeep Singh; Mittal, Sonam; Loka, Mariam; Aggarwal, Vaishali; Aggarwal, Diwakar; Masurkar, Akshara; Kaur, Ginpreet; Varol, Mehmet; Sak, Katrin; Kumar, Manoj; Sethi, Gautam; Bishayee, Anupam (Elsevier, 2021)Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties. Deguelin, a natural ... -
Emodin: A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets
Tuli, Hardeep Singh; Aggarwal, Vaishali; Tuorkey, Muobarak; Aggarwal, Diwakar; Parashar, Nidarshana Chaturvedi; Varol, Mehmet; Savla, Raj; Kaur, Ginpreet; Mittal, Sonam; Sak, Katrin (Elsevier, 2021)Oncogenic transformation has been the major cause of global mortality since decades. Despite established therapeutic regimes, majority of cancer patients either present with tumor relapse, refractory disease or therapeutic ... -
Extracellular microRNAs: key players to explore the outcomes of in vitro fertilization
Khan, Haroon Latif; Bhatti, Shahzad; Abbas, Sana; Kaloǧlu, Celal; Isa, Ahmed Mostafa; Younas, Hooria; Ziders, Rachel; Yıldız, Ayşegül (BioMed Central Ltd, 2021)Background: MicroRNAs (miRNAs) are small RNA molecules that modulate post-transcriptional gene regulation. They are often used as promising non-invasive biomarkers for the early diagnosis of cancer. However, their roles ... -
Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone
Varol, Mehmet; Tuli, Hardeep Singh; Kumar, Ajay; Sak, Katrin; Aggarwal, Diwakar; Gupta, Dhruv Sanjay; Çapanoğlu,Esra (MDPI, 2022)It is well known that, historically, plants have been an important resource of anticancer agents, providing several clinically approved drugs. Numerous preclinical studies have shown a strong anticancer potential of ... -
Licorice ( Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
Tuli, Hardeep Singh; Garg, Vivek Kumar; Mehta, Jinit K.; Kaur, Ginpreet; Mohapatra, Ranjan K.; Varol, Mehmet (Dove Press, 2022)Cancer is a highly lethal disease, and its incidence has rapidly increased worldwide over the past few decades. Although chemotherapeutics and surgery are widely used in clinical settings, they are often insufficient to ... -
Modification of multi-walled carbon nanotubes with platinum-osmium to develop stable catalysts for direct methanol fuel cells
Bekmezci, Muhammed; Güleş, Gamze Nur; Bayat, Ramazan; Şen, Fatih (Royal Society of Chemistry, 2023)In the study, a new bimetallic catalyst was synthesized for methanol oxidation using multi-walled carbon nanotube (MWCNT)-supported platinum-osmium (PtOs) nanoparticles (PtOs@MWCNT NPs). The morphological structures of the ... -
Molecular dynamics analysis of N-acetyl-D-glucosamine against specific SARS-CoV-2’s pathogenicity factors
Baysal, Ömür; Ghafoor, Naeem Abdul; Silme, Ragıp Soner; Ignatov, Alexander N.; Kniazeva, Volha (Public Library of Science, 2021)The causative agent of the pandemic identified as SARS-CoV-2 leads to a severe respiratory illness similar to SARS and MERS with fever, cough, and shortness of breath symptoms and severe cases that can often be fatal. In ... -
Nodal tumor volume as a prognostic factor for head and neck squamous cell carcinoma: a systematic review
Moumoulidis, Paris T.; Paylopoulou, Athanasia; Ünal, Reşat; Mavragani, Ifigeneia; Georgakilas, Alexandros G.; Kyrodimos, Efthymios (FRONTIERS IN BIOSCIENCE INC, 2021)Introduction: Several studies suggest that there is an association between the metastatic nodal tumor volume and the clinical outcome in patients with solid cancers. However, despite the prognostic potential of nodal volume, ... -
NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target
Aggarwal, Vaishali; Tuli, Hardeep Singh; Varol, Mehmet (Elsevier, 2021)Notch signaling, an evolutionarily conserved signaling cascade, is critical for normal biological processes of cell differentiation, development, and homeostasis. Deregulation of the Notch signaling pathway has been ... -
Phloretin, as a Potent Anticancer Compound: From Chemistry to Cellular Interactions
Tuli, Hardeep Singh; Rath, Prangya; Chauhan, Abhishek; Ramniwas, Seema; Vashishth, Kanupriya; Varol, Mehmet (MDPI, 2022)Phloretin is a natural dihydrochalcone found in many fruits and vegetables, especially in apple tree leaves and the Manchurian apricots, exhibiting several therapeutic properties, such as antioxidant, antidiabetic, ... -
The Prevalence and Genetic Characterization of Strains of Borrelia Isolated from Ixodes Tick Vectors in Belarus (2012-2019)
Kniazeva, Volha; Baysal, Ömür; Krasko, Anatoli; Iwaniak, Wojciech; Higgs, Stephen (Mary Ann Liebert, 2021)Borrelia burgdorferi sensu lato (s.l.) is the most common pathogen of medical significance transmitted by ticks of the family Ixodidae in Belarus. Human infection with B. burgdorferi causes Lyme borreliosis, most commonly ... -
Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies
Akbar, Rahmad; Bashour , Habib; Rawat, Puneet; Robert, Philippe A.; Zengin, Talip (TAYLOR & FRANCIS INC, 2022)Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs) are tremendous, the design and discovery of new candidates remain a time and cost-intensive endeavor. In this regard, progress in the ... -
Salicylidene acylhydrazides attenuate survival of SH-SY5Y neuroblastoma cells through affecting mitotic regulator Speedy/RINGO and ERK/MAPK-PI3K/AKT signaling
Arzıman, Süleyman; Tanrıverdi, Özgür; Küçükvardar, Seren; Çitil, Neslihan; Yıldız, Ayşegül (Humana Press Inc, 2020)Salicylidene acylhydrazide group synthetic compounds ME0053, ME005 and ME0192 are known for their iron chelating properties and due to these properties they are primarily used for blocking the bacterial type 3 secretory ... -
Synthesis, Structural Investigations, and In Vitro/In Silico Bioactivities of Flavonoid Substituted Biguanide: A Novel Schiff Base and Its Diorganotin (IV) Complexes
Abbas, Zahoor; Kumar, Manoj; Tuli, Hardeep Singh; M Janahi, Essam; Haque, Shafiul ; Harakeh, Steve; Varol, Mehmet (MDPI, 2022)Quercetin is one of the most powerful bioactive dietary flavonoids. The in vivo biological study of quercetin is extremely difficult due to its very low solubility. However, diorganotin complexes of quercetin are more ... -
Targeted mesoporous silica nanoparticles for improved inhibition of disinfectant resistant Listeria monocytogenes and lower environmental pollution
Sudağıdan, Mert; Yıldız, Gülşah; Önen, Selin; Al, Rabia; Nur temiz, S. Şevval; Zafer Yurt, Mediha Nur; Tepebaşı, Behiye Büşra; Acar, Elif Esma; Çoban, Ayşen; Aydın, Ali; Dursun, Ali D.; Özalp, Veli G. (Elsevier B.V., 2021)Benzalkonium chloride (BAC) is a common ingredient of disinfectants used for industrial, medical, food safety and domestic applications. It is a common pollutant detected in surface and wastewaters to induce adverse effects ... -
Targeting MDM2-p53 Axis through Drug Repurposing for Cancer Therapy: A Multidisciplinary Approach
Yıldız, Ayşegül; Ghafoor, Naeem Abdul (PMC, 2023)Cancer remains a major cause of morbidity and mortality worldwide, and while current therapies, such as chemotherapy, immunotherapy, and cell therapy, have been effective in many patients, the development of novel therapeutic ...