Kurum Yazarı "Demircan, Turan" PubMed İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Cellular and Molecular Comparison of Glioblastoma Multiform Cell Lines
Demircan, Turan; Yavuz, Mervenur; Kaya, Egemen; Akgül, Sıddıka; Altuntaş, Ebru (CUREUS INC, 2021)Glioblastoma multiform (GBM) is one of the most severe tumor types. It is highly invasive and characterized as a grade IV neoplastic cancer. Its resistance to chemotherapy-temozolomide (TMZ treatment)-in combination with ... -
Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl
Sibai, Mustafa; Altuntas, Ebru; Süzek, Barış Ethem; Sahin, Betul; Parlayan, Cuneyd; Ozturk, Gurkan; Demircan, Turan (Academic Press Inc Elsevier Science, 2020)The axolotl (Ambystoma mexicanum) salamander, a urodele amphibian, has an exceptional regenerative capacity to fully restore an amputated limb throughout the life-long lasting neoteny. By contrast, when axolotls are ... -
Hydroquinidine displays a significant anticarcinogenic activity in breast and ovarian cancer cells via inhibiting cell-cycle and stimulating apoptosis
Yavuz, Mervenur; Demircan, Turan; Şahin, Betül; Baykal, Ahmet Tarık (TUBITAK, 2023)Breast and ovarian cancers are women’s most commonly diagnosed cancers. Seeking an efficient anticarcinogenic compound is still a top priority regarding the aggressiveness of these cancers and the limited benefit of current ... -
Integrative Analysis of Axolotl Gene Expression Data from Regenerative and Wound Healing Limb Tissues
Sibai, Mustafa; Parlayan, Cüneyd; Tuğlu, Pelin; Özturk, Gürkan; Demircan, Turan (Nature Research, 2019)Axolotl (Ambystoma mexicanum) is a urodele amphibian endowed with remarkable regenerative capacities manifested in scarless wound healing and restoration of amputated limbs, which makes it a powerful experimental model for ... -
m 6 A Pathway Regulators Are Frequently Mutated in Breast Invasive Carcinoma and May Play an Important Role in Disease Pathogenesis
Demircan, Turan; Yavuz, Mervenur; Akgül, Sıddıka (Mary Ann Liebert, 2021)Breast invasive carcinoma (BIC) is one of the most commonly observed and the deadliest cancer among women. Studies examining the role of epigenetics and regulation of gene expression stand to make important strides in ... -
Microbiome and Longevity: High Abundance of Longevity-Linked Muribaculaceae in the Gut of the Long-Living RodentSpalax leucodon
Sibai, Mustafa; Altuntaş, Ebru; Yıldırım, Berna; Öztürk, Gürkan; Yıldırım, Süleyman; Demircan, Turan (Mary Ann Liebert, Inc, 2020)With a world population living longer as well as marked disparities in life expectancy, understanding the determinants of longevity is one of the priority research agendas in 21st century life sciences. To this end, the ... -
Preclinical Molecular Signatures of Spinal Cord Functional Restoration: Optimizing the Metamorphic Axolotl (Ambystoma mexicanum) Model in Regenerative Medicine
Demircan, Turan; Hacibektasogu, Harbiye; Sibai, Mustafa; Fescioglu, Ece Cana; Altuntaş, Ebru; Ozturk, Gurkan; Süzek, Barış Ethem (Mary Ann Liebert, Inc, 2020)Regenerative medicine offers hope for patients with diseases of the central and peripheral nervous system. Urodele amphibians such as axolotl display an exceptional regenerative capacity and are considered as essential ... -
A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling pathway
Yavuz, Mervenur; Takanlou, Leila Sabour; Avcı, Çığır Biray; Demircan, Turan (Elsevier B.V., 2023)Hepatocellular carcinoma (HCC) is a major global health problem that often correlates with poor prognosis. Due to the insufficient therapy options with limited benefits, it is crucial to identify new therapeutic approaches ...