Yazar "MÜ, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü" için Moleküler Biyoloji ve Genetik Bölümü Koleksiyonu listeleme
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Deguelin targets multiple oncogenic signaling pathways to combat human malignancies
Tuli, Hardeep Singh; Mittal, Sonam; Loka, Mariam; Aggarwal, Vaishali; Aggarwal, Diwakar; Masurkar, Akshara; Kaur, Ginpreet; Varol, Mehmet; Sak, Katrin; Kumar, Manoj; Sethi, Gautam; Bishayee, Anupam (Elsevier, 2021)Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties. Deguelin, a natural ... -
Development of an optimum proliferation medium via the graph kernel statistical analysis method for genetically stable in vitro propagation of endemic Thymus cilicicus (Turkey)
Kaya, Ergun; Akgüller, Ömer; Mercan, Taner; Güldağ, Sevinç; Özkaya, Damla Ekin; Öztürk, Bilge; Çelik, Onur; Aktay, İrem (Department of Biology, Faculty of Science, University of Zagreb, 2021)Thymus cilicicus is an endemic Eastern Mediterranean element that has aromatic-medicinal properties. Its natural population spreads across gravelly ground and open rocky areas of South and Southwest Anatolia. The current ... -
Doxorubicin Release from Bovine Serum Albumin Microparticles
Gülsu, Aydan; Aslanpay, Mutlu Can; Alper, Mehlika; Güneş, Hatice (SPRINGER, 2022)Doxorubicin (Dox) is an anthracycline antibiotic and highly potent anticancer drug. However, its utility is often limited by severe side effects such as irreversible cardiotoxicity and reversible nephrotoxicity. In recent ... -
The effect of a seed coating with Origanum vulgare essential oil on Clavibacter michiganensis subsp. michiganensis
Yılmaz, Meral; Baysal, Ömür; Silme, Ragıp Soner (Czech Academy of Agricultural Sciences, 2021)The study aimed to evaluate the efficacy of a seed film coating with Origanum vulgare Linnaeus essential oil (EO) against Clavibacter michiganensis subsp. michiganensis (Cmm) on tomatoes. Tomato seeds (cv. Rio Grande) ... -
The effects of the Rheum ribes plant extract on inflammation, extracellular matrix remodeling, and obesity suggest a therapeutic potential
Kaya, Hasret; Tokgöz, Hilal Büşra; Ünal, Reşat; Altan, Filiz (Springer Science and Business Media B.V., 2023)Background: The prevalence of obesity is increasing in the world, and the Type II diabetes associated with obesity led researchers to seek alternative methods to treat these two chronic diseases. In the case of obesity and ... -
Emodin: A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets
Tuli, Hardeep Singh; Aggarwal, Vaishali; Tuorkey, Muobarak; Aggarwal, Diwakar; Parashar, Nidarshana Chaturvedi; Varol, Mehmet; Savla, Raj; Kaur, Ginpreet; Mittal, Sonam; Sak, Katrin (Elsevier, 2021)Oncogenic transformation has been the major cause of global mortality since decades. Despite established therapeutic regimes, majority of cancer patients either present with tumor relapse, refractory disease or therapeutic ... -
Evaluation of Critical Points for Effective Cryopreservation of Four Different Citrus spp. Germplasm
Özkaya Ekin, Damla; Souza, Fernanda Vidigal Duarte; Kaya, Ergun (MDPI, 2022)The different pre- and post-treatments are critical in cryopreservation procedures and affect the shoot tip regrowth after freezing. In the present study, the long-term storage of four citrus cultivars [Bodrum Mandarin ... -
Extracellular microRNAs: key players to explore the outcomes of in vitro fertilization
Khan, Haroon Latif; Bhatti, Shahzad; Abbas, Sana; Kaloǧlu, Celal; Isa, Ahmed Mostafa; Younas, Hooria; Ziders, Rachel; Yıldız, Ayşegül (BioMed Central Ltd, 2021)Background: MicroRNAs (miRNAs) are small RNA molecules that modulate post-transcriptional gene regulation. They are often used as promising non-invasive biomarkers for the early diagnosis of cancer. However, their roles ... -
Genetic diversity of the cosmopolitan long-legged fly Syntormon pallipes in Turkey
Tonguç, Alper; Yüzer, Ömer; Doğaç, Ersin (Taylor and Francis Ltd., 2023)Syntormon pallipes is one of the cosmopolitan species in the family Dolichopodidae. It has an important role in agriculture and forest ecosystems. We studied the genetic diversity of 10 populations of this species using ... -
GENETIC UNIFORMITY OF A SPECIFIC REGION IN SARS-CoV-2 GENOME AND REPURPOSING OF N-ACETYL-D-GLUCOSAMINE
Baysal, Ömür; Silme, Ragıp Soner; Karaaslan, Çağatay; Ignatov, Alexander N. (PARLAR SCIENTIFIC PUBLICATIONS (P S P), 2021)The causative agent of the viral pneumonia outbreak in the world identified as SARS-CoV-2 leads to a severe respiratory illness like SARS and MERS. The pathogen spreading has turned into a pandemic dissemination and increased ... -
GENOMIC CHARACTERIZATION AND PHYTOSTIMULATIVE EFFECT OF A NOVEL SERRATIA SPECIES
Çetinkaya, Agit; Baysal, Ömür; Silme, Ragıp Soner; Azim, M. Kamran; Saleem, Faizan (Serbian Genetics Society, 2022)Some of non-pathogenic bacteria are effective biocontrol agents and plant growth inducers besides its degradative property on polycyclic aromatic hydrocarbons (PAH). Herein, we report a novel candidate Serratia species ... -
Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone
Varol, Mehmet; Tuli, Hardeep Singh; Kumar, Ajay; Sak, Katrin; Aggarwal, Diwakar; Gupta, Dhruv Sanjay; Çapanoğlu,Esra (MDPI, 2022)It is well known that, historically, plants have been an important resource of anticancer agents, providing several clinically approved drugs. Numerous preclinical studies have shown a strong anticancer potential of ... -
Host-Induced Gene Silencing: Approaches in Plant Disease Management
Baysal, Ömür; Baştaş, Kubilay Kurtuluş (Springer International Publishing, 2023)Crops exposed to the damage of various biotic and abiotic sources result in reduced yields and cause economic losses. There are prominent strategies such as breeding for improved resistance, the application of pesticides, ... -
The ichthyofaunal diversity of freshwater ecosystems in Gökçeada island (NW Turkey) under the pressure of nonnative species
Ağdamar, Sevan; Saç, Gülşah; Gaygusuz, Özcan; Doğaç, Ersin; Acar, Ümit; Gürsoy Gaygusuz, Çiğdem; Özuluğ, Müfit (Turkiye Klinikleri, 2021)Freshwater ecosystems have a greater value for biodiversity per surface area than terrestrial and marine ecosystems. Streams and lakes are notably prone to biodiversity loss, being the greatest threats habitat destructions ... -
In vitro DNA interaction, topoisomerase I/II Inhibition and cytotoxic properties of polymeric copper(II) complex bridged with perchlorate ion containing N-4-type schiff base ligand
Topkaya, Cansu Gökçe; Göktürk, Tolga; Hökelek, Tuncer; Sakallı Çetin, Esin; Kıncal, Sultan; Güp, Ramazan (Elsevier, 2022)Cu(II) complex containing p-Cl-isonitrosoacetophenone based on N 4-type Schiff base ligand was synthesized and characterized by elemental analysis, FTIR, H-1 NMR, (13) C NMR and UV-Visible. The crystal structure of the ... -
In vitro Regeneration and Synthetic Seed Production of Colchicum cilicicum Grown Naturally in Turkey
Yalçın Mendi, N. Yeşim; Özdemir, Şamil; Uğur, Senem; Sevindik, Başar; İzgü, Tolga; Kaya, Ergün; Tütüncü, Mehmet (Gıda, Tarım ve Hayvancılık Bakanlığı, 2022)Colchicum belongs to the Colchicaceae family and is naturally distributed in Turkey with 36 taxa. Colchicum species is known for both its medicinal aromatic and ornamental properties. In this study, Colchicum cilicium corms ... -
Investigation of modified WPM medium for the best meristem proliferation of corylus avellana L
Kıvrak kıran, S.; Galatalı, Selin; Yeniocak, S.; Özkaya, D. E.; Mercan, T. (AHSCF, 2021)Cultivation of Corylus avellana L. in Turkey is performed generally in the northern regions where it is an important source of livelihood for the local farmers. More than 70% of world hazelnut production is supplied by ... -
Licorice ( Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
Tuli, Hardeep Singh; Garg, Vivek Kumar; Mehta, Jinit K.; Kaur, Ginpreet; Mohapatra, Ranjan K.; Varol, Mehmet (Dove Press, 2022)Cancer is a highly lethal disease, and its incidence has rapidly increased worldwide over the past few decades. Although chemotherapeutics and surgery are widely used in clinical settings, they are often insufficient to ... -
MasPA: A Machine Learning Application to Predict Risk of Mastitis in Cattle from AMS Sensor Data
Abdul Ghafoor, Naeem; Sitkowska, Beata (MDPI, 2021)Mastitis is a common disease that prevails in cattle owing mainly to environmental pathogens; they are also the most expensive disease for cattle in dairy farms. Several prevention and treatment methods are available, ... -
Metal nanoparticles in cancer: from synthesis and metabolism to cellular interactions
Tuli, Hardeep Singh; Joshi, Ruchira; Kaur, Ginpreet; Garg, Vivek Kumar; Sak, Katrin; Varol,Mehmet (SPRINGER HEIDELBERG, 2022)Nanotechnology has encouraged new and amended materials (metal nanoparticles) for therapeutic applications with specific prominence in healthcare. Metal nanoparticles (NPs) are versatile nanoscale entities, widely used to ...