Yazar "Yıldız, Ayşegül" için Moleküler Biyoloji ve Genetik Bölümü Koleksiyonu listeleme
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Extracellular microRNAs: key players to explore the outcomes of in vitro fertilization
Khan, Haroon Latif; Bhatti, Shahzad; Abbas, Sana; Kaloǧlu, Celal; Isa, Ahmed Mostafa; Younas, Hooria; Ziders, Rachel; Yıldız, Ayşegül (BioMed Central Ltd, 2021)Background: MicroRNAs (miRNAs) are small RNA molecules that modulate post-transcriptional gene regulation. They are often used as promising non-invasive biomarkers for the early diagnosis of cancer. However, their roles ... -
p60-katanin: a novel interacting partner for p53
Korulu, Sirin; Yıldız, Ayşegül (Springer, 2020)Katanin, one of the best-characterized microtubule (MT) severing proteins, is composed of two subunits: catalytic p60-katanin, and regulatory p80-katanin. p60-katanin triggers MT reorganization by severing them. MT ... -
Salicylidene acylhydrazides attenuate survival of SH-SY5Y neuroblastoma cells through affecting mitotic regulator Speedy/RINGO and ERK/MAPK-PI3K/AKT signaling
Arzıman, Süleyman; Tanrıverdi, Özgür; Küçükvardar, Seren; Çitil, Neslihan; Yıldız, Ayşegül (Humana Press Inc, 2020)Salicylidene acylhydrazide group synthetic compounds ME0053, ME005 and ME0192 are known for their iron chelating properties and due to these properties they are primarily used for blocking the bacterial type 3 secretory ... -
Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells
Kaya, Yeşim; Küçükvardar, Seren; Yıldız, Ayşegül (Springer, 2020)Abnormal activity of ERK/MAPK and PI3K/AKT pathways is one of the most important factors for the development of many cancer types including neuroblastoma cancer. Apart from these two pathways, some cell cycle regulators ... -
Targeting MDM2-p53 Axis through Drug Repurposing for Cancer Therapy: A Multidisciplinary Approach
Yıldız, Ayşegül; Ghafoor, Naeem Abdul (PMC, 2023)Cancer remains a major cause of morbidity and mortality worldwide, and while current therapies, such as chemotherapy, immunotherapy, and cell therapy, have been effective in many patients, the development of novel therapeutic ...