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dc.contributor.authorTanrıverdi, Özgür
dc.contributor.authorMenekse, Serkan
dc.contributor.authorTeker, Fatih
dc.contributor.authorOktay, Esin
dc.contributor.authorPilanci, Kezban Nur
dc.contributor.authorGunaldi, Meral
dc.contributor.authorYanmaz, Mustafa Teoman
dc.date.accessioned2020-11-20T15:02:16Z
dc.date.available2020-11-20T15:02:16Z
dc.date.issued2016
dc.identifier.issn1107-0625
dc.identifier.urihttps://hdl.handle.net/20.500.12809/2448
dc.descriptionTEKER, FATIH/0000-0003-4693-6587en_US
dc.descriptionWOS: 000383306700010en_US
dc.descriptionPubMed ID: 27685904en_US
dc.description.abstractPurpose: To determine the predictive value of the mean platelet volume (MPV) and the MPV/platelet count ratio on the development of isolated bone metastasis in patients with breast cancer. Methods: A total of 121 previously untreated female patients with isolated bone metastases from breast cancer (group 1) were included in this retrospective cohort study. The patients enrolled in this study had similar age, biological subtypes, and duration of follow-up after diagnosis. Group 1 was compared with both 71 previously untreated women with breast cancer with no metastases at all (group 2) and 39 healthy women (group 3). Demographic data, laboratory tests and histological features of all of the patients in groups 1 and 2 were recorded and the study variables from each of the three groups were compared. Results: In group 1, the cut-off value (9.2 fL) for the MPV was determined and patients were stratified into 4 subgroups. The MPV was higher in group 1 than in either group 2 or group 3. Group 1 patients had a MPV of 8.8 +/- 3.1 fL (mean 5.1, range: 6.1-15.6) and the cut-off value for MPV was 9.2fl. For patients in group 1, the MPV distribution was stratified into 4 groups as follows: group A included MPV values <6.08 fL, in group B values ranged from 6.09 to 8.46 fL, group C included values from 8.47 to 10.05 fL, and group D included patients with MPV values >10.06fL. MPV and the presence of lymphovascular invasion were found to be independent risk factors for the development of isolated bone metastases. Conclusion: We concluded that MPV can be used to predict the development of isolated bone metastases.en_US
dc.item-language.isoengen_US
dc.publisherZerbinis Medical Publen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Metastasesen_US
dc.subjectBreast Canceren_US
dc.subjectMean Platelet Volumeen_US
dc.subjectPlatelet Counten_US
dc.titleThe mean platelet volume may predict the development of isolated bone metastases in patients with breast cancer: a retrospective study of the Young Researchers Committee of the Turkish Oncology Group (TOG)en_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Tanriverdi, Ozgur] Mugla Sitki Kocman Univ, Fac Med, Dept Med Oncol, Mugla, Turkey -- [Menekse, Serkan] Celal Bayar Univ, Fac Med, Dept Med Oncol, Manisa, Turkey -- [Teker, Fatih] Ondokuz Mayis Univ, Fac Med, Dept Med Oncol, Samsun, Turkey -- [Oktay, Esin] Adnan Menderes Univ, Dept Med Oncol, Fac Med, Aydin, Turkey -- [Pilanci, Kezban Nur] Bilim Univ, Fac Med, Dept Med Oncol, Istanbul, Turkey -- [Gunaldi, Meral] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkeyen_US
dc.identifier.volume21en_US
dc.identifier.issue4en_US
dc.identifier.startpage840en_US
dc.identifier.endpage850en_US
dc.relation.journalJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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