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Effects of Exercise and Detraining on Genes Involved in the Synthesis of Nitric Oxide, Carbon Monoxide in Spontaneously Hypertensive Rats

Date

2015

Author

Toprak, Emine Kılıç
Erkek, Özgen Kılıç
Mete, Gülçin Abban
Caner, Vildan
Barış, Cansu
Turhan, Gürkan
Bor Küçükatay, Melek
Kuru, Oktay

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Abstract

Background: We aimed to determine the effects of exercise followed by detraining on systolic blood pressure (SBP), heme oxygenase 2 (HO-2) expression, and carboxyhemoglobin (COHb) concentration in spontaneously hypertensive rats (SHR) to explain the role of carbon monoxide (CO) in this process. Material/Methods: Animals were randomized into exercised and detrained groups. Corresponding sedentary rats were grouped as Time 1–2. Swimming of 60 min/5 days/week for 10 weeks was applied. Detraining rats discontinued training for an additional 5 weeks. Gene and protein expressions were determined by real-time PCR and immunohistochemistry. Results: Aorta HO-2 histological scores (HSCORE) of hypertensive rats were lower, while SBP was higher. Swimming caused enhancement of HO-2 immunostaining in aorta endothelium and adventitia of SHR. Exercise induced elevation of blood COHb index in SHR. Synchronous BP lowering effect of exercise was observed. HO-2 mRNA expression, HSCORE, and blood COHb index were unaltered during detraining, while SBP was still low in SHR. Conclusions: CO synthesized by HO-2 at least partly plays a role in SBP regulation in the SHR- and BP-lowering effect of exercise. Regular exercise with short-term pauses may be advised to both hypertensives and individuals who are at risk.

Source

Acta Physiologica

Volume

215

URI

https://hdl.handle.net/20.500.12809/2948

Collections

  • Fizyoterapi ve Rehabilitasyon Bölümü Koleksiyonu [50]
  • WoS İndeksli Yayınlar Koleksiyonu [6466]



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