Effects of Exercise and Detraining on Genes Involved in the Synthesis of Nitric Oxide, Carbon Monoxide in Spontaneously Hypertensive Rats
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Date
2015Author
Toprak, Emine KılıçErkek, Özgen Kılıç
Mete, Gülçin Abban
Caner, Vildan
Barış, Cansu
Turhan, Gürkan
Bor Küçükatay, Melek
Kuru, Oktay
Metadata
Show full item recordAbstract
Background: We aimed to determine the effects of exercise followed by detraining on systolic blood pressure (SBP), heme
oxygenase 2 (HO-2) expression, and carboxyhemoglobin (COHb) concentration in spontaneously hypertensive
rats (SHR) to explain the role of carbon monoxide (CO) in this process.
Material/Methods: Animals were randomized into exercised and detrained groups. Corresponding sedentary rats were grouped as
Time 1–2. Swimming of 60 min/5 days/week for 10 weeks was applied. Detraining rats discontinued training for an
additional 5 weeks. Gene and protein expressions were determined by real-time PCR and immunohistochemistry.
Results: Aorta HO-2 histological scores (HSCORE) of hypertensive rats were lower, while SBP was higher. Swimming
caused enhancement of HO-2 immunostaining in aorta endothelium and adventitia of SHR. Exercise induced
elevation of blood COHb index in SHR. Synchronous BP lowering effect of exercise was observed. HO-2 mRNA
expression, HSCORE, and blood COHb index were unaltered during detraining, while SBP was still low in SHR.
Conclusions: CO synthesized by HO-2 at least partly plays a role in SBP regulation in the SHR- and BP-lowering effect of exercise.
Regular exercise with short-term pauses may be advised to both hypertensives and individuals who are at risk.