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dc.contributor.authorAvci, Nilufer
dc.contributor.authorDeligonul, Adem
dc.contributor.authorTolunay, Sahsine
dc.contributor.authorCubukcu, Erdem
dc.contributor.authorOlmez, Omer Fatih
dc.contributor.authorAltmisdortoglu, Ozgur
dc.contributor.authorEvrensel, Turkkan
dc.date.accessioned2020-11-20T15:05:23Z
dc.date.available2020-11-20T15:05:23Z
dc.date.issued2015
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.urihttps://hdl.handle.net/20.500.12809/3010
dc.descriptionaksoy, asude/0000-0002-5609-9658en_US
dc.descriptionWOS: 000361421900007en_US
dc.descriptionPubMed ID: 26416041en_US
dc.description.abstractPurpose: The presence of a pronounced tumor lymphocytic infiltrate (TLI) is deemed to reflect the presence of an immunoinflammatory response against the tumor and may thus have prognostic significance. We investigated the prognostic value of TLI detected in pathological specimens collected following neoadjuvant chemotherapy (NACT) in patients with breast cancer. Methods: 100 consecutive patients with breast cancer (mean age 47.8 +/- 11.4 years) who were scheduled to undergo anthracycline- and/or taxane-containing NACT were enrolled. Specimens collected after NACT were scored with the 4-point Klintrup scoring criteria for the presence of TLI. Results: 60 patients had low-grade TLI and 40 high-grade TLI. Comparison of the patient population according to low-grade vs high-grade TLI revealed statistically significant difference both in terms of disease-free survival (DFS) (log rank=4.28, p<0.05) and overall survival (OS) (log rank=3.96, p<0.05), with high-grade TLI patients showing a better prognosis. Multivariate Cox regression analysis identified postoperative tumor size and low-grade TLI as the two main independent adverse prognostic factors. Conclusion: High-grade TLI may interfer with tumor growth and can represent a favorable prognostic factor in women with breast cancer undergoing NACT.en_US
dc.item-language.isoengen_US
dc.publisherImprimatur Publicationsen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectNeoadjuvant Chemotherapyen_US
dc.subjectPrognosisen_US
dc.subjectTumor Lymphocytic Infiltratesen_US
dc.titlePrognostic impact of tumor lymphocytic infiltrates in patients with breast cancer undergoing neoadjuvant chemotherapyen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Avci, Nilufer; Cubukcu, Erdem] Ali Osman Sonmez Oncol Hosp, Dept Med Oncol, Osmangazi, Bursa, Turkey -- [Deligonul, Adem; Kurt, Ender; Evrensel, Turkkan] Uludag Univ, Fac Med, Dept Med Oncol, Bursa, Turkey -- [Tolunay, Sahsine] Uludag Univ, Fac Med, Dept Pathol, Bursa, Turkey -- [Olmez, Omer Fatih] Medipol Univ, Sch Med, Dept Med Oncol, Istanbul, Turkey -- [Altmisdortoglu, Ozgur] Balikesir State Hosp, Dept Radiat Oncol, Balikesir, Turkey -- [Tanriverdi, Ozgur] Mugla Sitki Kocman Univ, Dept Med Oncol, Mugla, Turkeyen_US
dc.identifier.volume20en_US
dc.identifier.issue4en_US
dc.identifier.startpage994en_US
dc.identifier.endpage1000en_US
dc.relation.journalJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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