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dc.contributor.authorTanrıverdi, Özgür
dc.contributor.authorCokmert, Suna
dc.contributor.authorOktay, Esin
dc.contributor.authorPilanci, Kezban Nur
dc.contributor.authorMenekse, Serkan
dc.contributor.authorKocar, Muharrem
dc.contributor.authorMeydan, Nezih
dc.date.accessioned2020-11-20T16:17:50Z
dc.date.available2020-11-20T16:17:50Z
dc.date.issued2014
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.urihttps://doi.org/10.1007/s12032-014-0217-z
dc.identifier.urihttps://hdl.handle.net/20.500.12809/3386
dc.descriptionSen, Cenk Ahmet/0000-0003-1043-8105en_US
dc.descriptionWOS: 000342079600034en_US
dc.descriptionPubMed ID: 25216865en_US
dc.description.abstractNon-small cell lung cancer (NSCLC) is one of the most common cancers. Most of the patients are inoperable at the time of diagnosis, and the prognosis is poor. Many prognostic factors have been identified in prior studies. However, it is not clear which factor is more useful. In this study, we investigated whether uric acid, the last breakdown product of purine metabolism in humans, has a prognostic significance in advanced NSCLC. A total of 384 NSCLC patients at stage IIIB/IV and who did not meet exclusion criteria were included in this retrospective cross-sectional study. The patients' serum uric acid levels before first-line chemotherapy and demographic (age, gender, smoking), clinical (performance status, weight loss, disease stage, first-line treatment regimen), laboratory (hemoglobin, lactate dehydrogenase), and histologic (histologic type, tumor grade) characteristics were recorded. First, a cut-off value was determined for serum uric acid level. Then, the patients were stratified into four groups (quartiles) based on their serum uric acid levels. Descriptive statistics, univariate and multivariate analyses, and survival analyses were used. Majority of the patients were males, smokers and metastatic at time of diagnosis and had history of weight loss and adenocarcinoma upon pathological examination. The serum uric acid levels of all patients were determined as 4.9 +/- 2.9 (range 1.9-11.3). The patients were stratified according to quartiles of serum uric acid concentration with cutoff values defined as <3.08 mg/dL (lowest quartile, Group 1), 3.09-5.91 mg/dL (Group 2), 5.92-7.48 mg/dL (Group 3), and >7.49 mg/dL (highest quartile, Group 4). Among the patients who had serum uric acid levels over 7.49, it was observed that those who also had squamous cell carcinoma had a greater rate of brain metastasis, a shorter time lapse until brain metastasis, and lower overall survival rate. It can be assumed that NSCLC patients who had histologically shown squamous cell carcinoma display brain metastasis and poor prognosis. It can be recommended to repeat this study with larger patient series including immunohistochemical, molecular, and wider laboratory investigations.en_US
dc.item-language.isoengen_US
dc.publisherHumana Press Incen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNon-Small Cell Lung Canceren_US
dc.subjectSerum Uric Aciden_US
dc.subjectPrognosisen_US
dc.titlePrognostic significance of the baseline serum uric acid level in non-small cell lung cancer patients treated with first-line chemotherapy: a study of the Turkish Descriptive Oncological Researches Groupen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Tanriverdi, Ozgur] Sitki Kocman Univ, Fac Med, Dept Med Oncol, Mugla, Turkey -- [Cokmert, Suna] Kent Hosp, Dept Med Oncol, Izmir, Turkey -- [Oktay, Esin; Meydan, Nezih] Adnan Menderes Univ, Fac Med, Dept Med Oncol, Aydin, Turkey -- [Pilanci, Kezban Nur; Ordu, Cetin] Bilim Univ, Fac Med, Dept Med Oncol, Istanbul, Turkey -- [Menekse, Serkan; Goksel, Gamze] Celal Bayar Univ, Fac Med, Dept Med Oncol, Manisa, Turkey -- [Kocar, Muharrem] Educ & Res Hosp, Dept Med Oncol, Sanliurfa, Turkeyen_US
dc.identifier.doi10.1007/s12032-014-0217-z
dc.identifier.volume31en_US
dc.identifier.issue10en_US
dc.relation.journalMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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