The role of Speedy/RINGO in between MAPK and AKT pathways in SH-SY5Y neuroblastoma cells

Abstract

Deregulated expression of the c-Myc oncogene is an important molecular hallmark of cancer. Previous studies have shown that the murine zinc finger protein ZF5 is a putative transcriptional regulator of c-Myc and can affect cell growth in mouse cell lines. The human zinc finger protein ZFP161 is 98% homologous to murine ZF5. The human gene Zfp161 is localized to 18p11.21 and cDNA of the gene has an open reading frame of 1347bp. We tested the regulatory effects of ZFP161 on c-Myc in human cells.