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dc.contributor.authorZorba, Orhan Unal
dc.contributor.authorKirbas, Serkan
dc.contributor.authorUzun, Hakki
dc.contributor.authorCetinkaya, Mehmet
dc.contributor.authorOnem, Kadir
dc.contributor.authorRifaioglu, Mehmet Murat
dc.date.accessioned2020-11-20T16:20:26Z
dc.date.available2020-11-20T16:20:26Z
dc.date.issued2013
dc.identifier.issn0042-1138
dc.identifier.issn1423-0399
dc.identifier.urihttps://doi.org/10.1159/000350940
dc.identifier.urihttps://hdl.handle.net/20.500.12809/3903
dc.descriptionWOS: 000327925400007en_US
dc.descriptionPubMed ID: 24296362en_US
dc.description.abstractBackground: The etiology of overactive bladder (OAB) remains unclear. Observed neurogenic factors in the literature are limited to suprapontine or spinal pathologies. The blink reflex is a useful tool in the evaluation of brainstem functions. Blink reflex latency times were evaluated in order to reveal pathology in the brainstem. Methods: A total of 60 women, 30 patients with idiopathic OAB and 30 healthy controls, were enrolled in the study. Blink reflex latency times were analyzed by electrical stimulation of the supraorbital nerve. Two responses in the orbicularis oculi muscle, early ipsilateral response (R1) and late bilateral response (R2) latency times, were recorded. Results: Mean ages of the patients and controls were 51.9 +/- 5.3 and 49.2 +/- 6.2 years, respectively. R2 latency times were significantly higher in patients than in controls. However, R1 latency times were similar between the two groups. Conclusions:The results of the study suggest a significant relation between late blink latencytimes and OAB. An oligosynaptic path via the trigeminal nuclei is responsible for R1; however, R2 response is relayed through the reticular formation. Stimulation of pontine reticular formation inhibits micturition contraction. In some patients, idiopathic OAB may result from reticular formation-originated pathology. Additional studies on other reticular formation-mediated reflexes are needed to reveal possible dysfunction of reticular formation. Copyright (C) 2013 S. Karger AG, Baselen_US
dc.item-language.isoengen_US
dc.publisherKargeren_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOveractive Bladderen_US
dc.subjectPonsen_US
dc.subjectReticular Formationen_US
dc.subjectBlink Reflexen_US
dc.titleOveractive Bladder and Pontine Reticular Formationen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Zorba, Orhan Unal; Uzun, Hakki] Recep Tayyip Erdogan Univ, Dept Urol, Fac Med, TR-53100 Rize, Turkey -- [Kirbas, Serkan] Recep Tayyip Erdogan Univ, Dept Neurol, Fac Med, TR-53100 Rize, Turkey -- [Cetinkaya, Mehmet] Mugla Univ, Fac Med, Dept Urol, Mugla, Turkey -- [Onem, Kadir] Ondokuz Mayis Univ, Fac Med, Dept Urol, Samsun, Turkey -- [Rifaioglu, Mehmet Murat] Mustafa Kemal Univ, Fac Med, Dept Urol, Antakya, Turkeyen_US
dc.identifier.doi10.1159/000350940
dc.identifier.volume91en_US
dc.identifier.issue4en_US
dc.identifier.startpage417en_US
dc.identifier.endpage422en_US
dc.relation.journalUrologia Internationalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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