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Fast-scanning high-flux microprobe for biological X-ray fluorescence microscopy and microXAS

dc.contributor.authorBarrea, R. A.
dc.contributor.authorGore, D.
dc.contributor.authorKujala, N.
dc.contributor.authorKaranfil, C.
dc.contributor.authorKozyrenko, S.
dc.contributor.authorHeurich, R.
dc.contributor.authorIrving, T. C.
dc.date.accessioned2020-11-20T16:34:01Z
dc.date.available2020-11-20T16:34:01Z
dc.date.issued2010
dc.identifier.issn0909-0495
dc.identifier.urihttps://doi.org/10.1107/S0909049510016869
dc.identifier.urihttps://hdl.handle.net/20.500.12809/4552
dc.descriptionWoloschak, Gayle/0000-0001-9209-8954; Paunesku, Tatjana/0000-0001-8698-2938en_US
dc.descriptionWOS: 000278885500012en_US
dc.descriptionPubMed ID: 20567085en_US
dc.description.abstractThere is a growing interest in the biomedical community in obtaining information concerning the distribution and local chemical environment of metals in tissues and cells. Recently, biological X-ray fluorescence microscopy (XFM) has emerged as the tool of choice to address these questions. A fast-scanning high-flux X-ray microprobe, built around a recently commissioned pair of 200 mm-long Rh-coated silicon Kirkpatrick-Baez mirrors, has been constructed at BioCAT beamline 18ID at the Advanced Photon Source. The new optical system delivers a flux of 1.3 x 10(12) photons s(-1) into a minimum focal spot size of similar to 3-5 mu m FWHM. A set of Si drift detectors and bent Laue crystal analyzers may be used in combination with standard ionization chambers for X-ray fluorescence measurements. BioCAT's scanning software allows fast continuous scans to be performed while acquiring and storing full multichannel analyzer spectra per pixel on-the-fly with minimal overhead time (< 20 ms per pixel). Together, the high-flux X-ray microbeam and the rapid-scanning capabilities of the BioCAT beamline allow the collection of XFM and micro X-ray absorption spectroscopy (microXAS) measurements from as many as 48 tissue sections per day. This paper reports the commissioning results of the new instrument with representative XFM and microXAS results from tissue samples.en_US
dc.description.sponsorshipNIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [RR08630]; US Department of Energy, Basic Energy Science, Office of Energy ResearchUnited States Department of Energy (DOE) [W-31-109-Eng-38]; National Cancer InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R21CA139386]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R21CA139386, R21CA139386] Funding Source: NIH RePORTER; NATIONAL CENTER FOR RESEARCH RESOURCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Research Resources (NCRR) [P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, 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P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, 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P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630, P41RR008630] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) [R01EB002100, R01EB002100, R01EB002100, R01EB002100, R01EB002100, R01EB002100, R01EB002100, R01EB002100] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622, P41GM103622] Funding Source: NIH RePORTERen_US
dc.description.sponsorshipBioCAT is a NIH-supported Research Center, RR08630. Use of the Advanced Photon Source was supported by the US Department of Energy, Basic Energy Science, Office of Energy Research, under Contract No. W-31-109-Eng-38. Project also supported by award number R21CA139386 from the National Cancer Institute. Dr Q. Ping Dou and Dr Di Chen (Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA) are gratefully acknowledged for kindly providing breast tumor tissue and normal kidney and liver samples. The content is solely the responsibility of the authors and does not necessarily reflect the official views of the National Center for Research Resources or the National Institutes of Health.en_US
dc.item-language.isoengen_US
dc.publisherWiley-Blackwellen_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSynchrotron X-Ray Imagingen_US
dc.subjectMicroprobeen_US
dc.subjectMicroarraysen_US
dc.subjectMicroxasen_US
dc.subjectMicrospectroscopyen_US
dc.subjectBiological Samplesen_US
dc.subjectTissuesen_US
dc.titleFast-scanning high-flux microprobe for biological X-ray fluorescence microscopy and microXASen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜen_US
dc.contributor.departmentTemp[Barrea, R. A.; Gore, D.; Kujala, N.; Kozyrenko, S.; Heurich, R.; Vukonich, M.; Irving, T. C.] IIT, Dept Biol Chem & Phys Sci, BioCAT, Chicago, IL 60616 USA -- [Karanfil, C.] Mugla Univ, Fac Arts & Sci, Dept Phys, TR-48187 Kotekli Mugla, Turkey -- [Huang, R.] Hauptman Woodward Inst, IMCA CAT, Buffalo, NY 14203 USA -- [Paunesku, T.; Woloschak, G.] Northwestern Univ, Feinberg Sch Med, Dept Radiat Oncol, Chicago, IL 60611 USA -- [Paunesku, T.; Woloschak, G.] Northwestern Univ, Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USAen_US
dc.identifier.doi10.1107/S0909049510016869
dc.identifier.volume17en_US
dc.identifier.startpage522en_US
dc.identifier.endpage529en_US
dc.relation.journalJournal of Synchrotron Radiationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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