Re: Yildiz BP, Bayraktaroglu M, Gunen H. Bronchodilator efficacy of tiotropium/formoterol (18/12 mu g once daily via a Discair inhaler), tiotropium alone (18 mu g by Handihaler) or combined with formoterol (12 mu g twice daily by Aerolizer) in adults with moderate-to-severe stable COPD. Curr Med Res Opin. 2019; 35(12):2187-2196

Abstract

In the study, we saw that 12 patients in the TIOmono group, 7 patients in the TIO/FORMbid group and 9 patients in the TIO/FORMfixed group had had exacerbations in the last year. In addition, the mean CAT score was 18.3 in the TIOmono group, 17.1 in the TIO/FORMbid group and 17.1 in the TIO/FORMfixed group. When compared with other groups, we saw that patients in the TIOmono group had more exacerbations and were more symptomatic in the last year. In patients with COPD, as the number of exacerbations and symptoms increase, the severity of the disease increases and response to inhaler therapy gets worse2 . We believe that this condition may affect the results of the study.