Yazar "Elbe, Hülya" için Tıp Fakültesi listeleme
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Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis
Haqi Ballur, Arwa Fadil; Altınöz, Eyüp; Yiğittürk, Gürkan; Özgül Önal, Melike; Elbe, Hülya (Springer, 2022)Gout is an inflammatory arthritis characterized by the deposition of monosodium urate (MSU) crystals in the joints or soft tissue. MSU crystals are potent inflammation inducers. Melatonin (MLT) is a powerful endogenous ... -
Leptin Accelerates Endothelial Wound Healing: Role of Endothelial Nitric Oxide Synthase Expression
Yiğittürk, Gürkan; Önal, Melike Özgül; Subaşı, Ekin; Doğan, Beyza; Türkmenoğlu, Melih; Kaplan, Merve; Yaşar, Volkan; Elbe, Hülya; Öztürk, Feral; 0000-0002-5315-253X (Turkish Society of Cardiology, 2022)Background: The endothelium is crucial for the control of vascular homeostasis and plays a role in angiogenesis. Leptin, a protein released mainly by adipose tissue, plays a key role in the regulation of energy balance and ... -
Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress
Altınöz, Eyüp; Öner, Zulal; Elbe, Hülya; Üremiş, Nuray; Üremiş, Muhammed (Taylor and Francis Ltd., 2021)The aim of the present study was to investigate the therapeutic and protective effects of linalool against doxorubicin (DOX)-induced kidney injury. Forty-eight Wistar rats were divided into 8 groups as follows; Control, ... -
Neuroprotection by melatonin against acrylamide-induced brain damage in pinealectomized rats
Biçer, Yasemin; Elbe, Hülya; Karayakalı, Melike; Yigittürk, Gürkan; Yılmaz, Ümit; Cengil, Osman; Al Gburi, Mohammed Raed Abdullah; Altınöz, Eyüp (Elsevier B.V., 2022)The current study aimed to evaluate the neuroprotective effect of exogenous melatonin against acrylamide (ACR)-induced oxidative stress and inflammatory and apoptotic responses in the brain tissues in pinealectomized rats ... -
Obesity and the Mother Goddess of Neolithic Çatalhöyük
Elbe, Hülya (Springer Science and Business Media Deutschland GmbH, 2023)Letter to Editor -
Pinealectomy and melatonin administration in rats: their effects on pulmonary edema induced by alpha-naphthylthiourea
Al Gburi, Mohammed Raed Abdullah; Altınöz, Eyüp; Elbe, Hülya; Yılmaz, ümit; Yılmaz, Nesibe; Karayakalı, Melike; Önal, Melike Özgül (TAYLOR & FRANCIS LTD, 2022)We aimed to observe the possible effects of melatonin (MLT) deprivation (pinealectomy) and exogenous MLT administration on pulmonary edema induced by alpha-naphthylthiourea (ANTU), a toxic chemical agent, in rats. Seventy ... -
The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats
Öner, Z.; Altinöz, E.; Elbe, Hülya; Ekinci, N. (Sage Publications Ltd, 2019)The aim of the present study was to determine the protective and therapeutic effects of linalool (LIN) against doxorubicin (DOX)-induced cardiotoxicity in rats histologically and biochemically. In experiments, 64 male ... -
Protective effects of quercetin against testis damage caused by cisplatin
Bostancıeri, Nuray; Taşlıdere, Aslı; Elbe, Hülya; Taşlıdere, Elif (Taylor and Francis Ltd., 2021)We investigated the effects of quercetin on cisplatin induced testicular toxicity using histopathological, immunohistochemical and biochemical methods. We used four groups of Wistar albino male: control, quercetin, cisplatin, ... -
Protective effects of sildenafil and resveratrol on ovarian ischemiareperfusion injury in rats
Ertürk, Nazile; Elbe, Hülya; Erdemli, Mehmet Erman; Aktas, Serdar; Yiğittürk, Gürkan; Aksungur, Zeynep; Öztürk, Feral; Süzen, Alev (Scientific Publishers of India, 2017)Aim: This study investigated the protective effects of sildenafil (SIL) and resveratrol (RSV) on ovarian ischemia-reperfusion (I/R) injury. Materials and methods: Forty-Eight Wistar albino rats were divided equally into ... -
Quercetin protection against ciprofloxacin induced liver damage in rats
Taşlıdere, E.; Doğan, Z.; Elbe, Hülya; Vardı, N.; Çetin, A.; Türköz, Y. (Taylor & Francis Ltd, 2016)Ciprofloxacin is a common, broad spectrum antibacterial agent; however, evidence is accumulating that ciprofloxacin may cause liver damage. Quercetin is a free radical scavenger and antioxidant. We investigated histological ... -
Resveratrol reduces light and electron microscopic changes in acetaminophen-induced hepatotoxicity in rats: Role of iNOS expression
Elbe, Hülya; Gül, Mehmet; Çetin, Aslı; Taşlıdere, Elif; Özyalın, Fatma; Türköz, Yusuf; Otlu, Ali (Taylor & Francis Inc, 2018)Introduction: Hepatotoxicity is amajor complication of acetaminophen (APAP), a widely used analgesic and antipyretic drug. Resveratrol (RSV) is a naturally occurring diphenol and it has anticancer, antioxidant, and ... -
Therapeutic role of melatonin on acrylamide-induced hepatotoxicity in pinealectomized rats: Effects on oxidative stress, NF-κB signaling pathway, and hepatocellular proliferation
Öztürk, İpek; Elbe, Hülya; Biçer, Yasemin; Karayakalı, Melike; Özgul-Önal, Melike; Altınöz, Eyüp (Elsevier Ltd, 2023)Acrylamide (AA) is formed in some foods by the cooking process at high temperatures, and it could be a carcinogen in humans and rodents. The purpose of the current study was to reveal the possible protective effects of ... -
Treatment with crocin suppresses diabetic nephropathy progression via modulating TGF-β1 and oxidative stress in an experimental model of pinealectomized diabetic rats
Keelo, Rihab Mudhafar Ali Hammood; Elbe, Hülya; Biçer, Yasemin; Yiğittürk, Gürkan; Koca, Oğuzhan; Karayakalı, Melike; Acar, Derya; Altınöz, Eyüp (Elsevier, 2022)One of the most common complications of diabetes is diabetic nephropathy (DN). Uncontrolled hyperglycemia leads to histopathologic alterations in the kidney that prevent normal renal function. This study aimed to explore ...