Yazar "0000-0002-9300-9324" için Tıp Fakültesi listeleme
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Evaluation of mTOR Activity in COPD Patients with Emphysema
Oral Tapan, Özge; Tapan, Utku; Edgünlü, Tuba; Doğan, Emrah (College of Physicians and Surgeons Pakistan, 2022)Objective: To evaluate the function of the mammalian target of the rapamycin (mTOR) pathway in chronic obstructive pulmonary disease (COPD) patients with emphysema. Study Design: Observational study. Place and Duration of ... -
Exploration of Potential miRNA Biomarkers and Prediction for Ovarian Cancer Using Artificial Intelligence
Hamidi, Farzaneh; Gilani, Neda; Belaghi, Reza Arabi; Sarbakhsh, Parvin; Edgünlü, Tuba; Santaguida, Pasqualina (MedGen, 2021)Ovarian cancer is the second most dangerous gynecologic cancer with a high mortality rate. The classification of gene expression data from high-dimensional and small-sample gene expression data is a challenging task. The ... -
Gene variants and serum levels of synaptic vesicle and presynaptic plasma membrane proteins in alcohol dependence and their relationship with impulsivity and temperament
Şenormancı, Güliz; Turan, Çetin; Karakaş Çelik, Sevim; Çelik, Aycan; Edgünlü Gökdoğan, Tuba; Bilgi, Ceren; Demir Akça, Ayşe Semra; Şenormancı, Ömer (UNIV SAOPAULO, 2021)Background: Exocytosis-related gene variants have been suggested to be associated with externalizing behaviors. Objective: This study aimed to examine VAMP2 26 bp Ins\Del, synaptotagmin XI (Syt11) rs3820594 and 33-bp ... -
Identifying Potential miRNA Biomarkers for Gastric Cancer Diagnosis Using Machine Learning Variable Selection Approach
Gialini, Neda; Belaghi, Reza Arabi; Aftabi, Younes; Faramarzi, Elnaz; Edgünlü, Tuba (Frontiers Media S.A., 2022)Aim: This study aimed to accurately identification of potential miRNAs for gastric cancer (GC) diagnosis at the early stages of the disease. Methods: We used GSE106817 data with 2,566 miRNAs to train the machine learning ... -
In Vitro Effects of Propofol on Cytotoxic, Apoptotic and PI3K-Akt Signaling Pathway Genes on Brain Cancer Cells
Gökdoğan Edgünlü, Tuba; Avcı, Cigir Biray; Özateş, Neslihan Pınar; Göker Bağca, Bakiye; Karakaş Çelik, Sevim; Bölük, Aydın; Uğur, Bakiye (Bentham Science, 2021)Aim: It was aimed to determine the cytotoxic and apoptotic effect of propofol on glioma cells. Background: Propofol [2,6-diisopropylphenol] is a commonly used intravenous anesthetic. Propofol is known to have a mechanism ... -
miR-181a-5p is a potential candidate epigenetic biomarker in multiple sclerosis
Edgünlü, Tuba; Görücü Yılmaz, Şenay; Emre, Ufuk; Taşdelen, Bahar; Kuru, Oktay; Kutlu, Gülnihal; Erdal, Mehmet Emin (NLM (Medline), 2022)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal degeneration. Abnormal expression of microRNAs (miRNAs) plays an important role in MS ... -
miR-181a-5p is a potential candidate epigenetic biomarker in sclerosis
Edgünlü, Tuba; Görücü Yılmaz, Şenay; Emre, Ufuk; Taşdelen, Bahar; Kuru, Oktay; Kutlu, Gülnihal; Erdal, Mehmet Emin (CANADIAN SCIENCE PUBLISHING, 2022)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal degeneration. Abnormal expression of microRNAs (miRNAs) plays an important role in MS ... -
Molecular and in silico analyses of SYN III gene variants in autism spectrum disorder
Barış, Remzi Oğuz; Şahin, Nilfer; Bilgiç, Ayşegül Demirtaş; Edgünlü, Tuba; Özdemir, Çilem (Springer Science and Business Media Deutschland GmbH, 2023)Background: Defects in neurotransmission and synaptogenesis are noteworthy in the pathogenesis of ASD. Synapsin III (SYN III) is defined as a synaptic vesicle protein that plays an important role in synaptogenesis and ... -
The role of adropin, salusin-α, netrin-1, and nesfatin-1 in endometriosis and their association with insulin resistance
Akbaba, Eren; Sezgin, Burak; Edgünlü, Tuba (GALENOS YAYINCILIK, 2021)Objective: The pathogenesis of endometriosis has not been clearly explained. Inflammatory factors of ectopic implantation and the growth of ectopic endometrial cells have been subjects of major interest. The number of ... -
The role of Wnt pathway antagonists in early-stage lung adenocarcinoma
Zeybek, Arife; Öz, Necdet; Kalemci ,Serdar; Tosun, Kürşad; Gökdoğan Edgünlü, Tuba; Kızıltuğ, Mehmet Tuğhan; Tekin, Leyla; Erdal, Mehmet Emin (Springer, 2021)Purpose We aimed to examine the expression levels of the genes encoding adenomatous polyposis coli (APC) 1, APC-2, Dickkopf related protein (DKK)-1, DKK-3, secreted frizzled-related protein (SFRP)-2, SFRP-4, and SFRP-5, ... -
A study of the correlation between the serum Latexin levels and the mTORC subunits Raptor and Rictor in the molecular pathogenesis of chronic lymphocytic leukemia
Pektaş, Gökhan; Karakuş, Volkan; Çetin, Deniz; Edgünlü, Tuba (Turaz Bilim, 2021)Abstract: Hematopoietic stem cells (HSCs) ensure the lifelong production of blood cells throughout a lifetime. Latexin (Lxn) is thought to have a tumor suppressor role and endogenously down-regulate the number of HSCs via ... -
Vesicle trafficking with snares: a perspective for autism
Özdemir, Çilem; Şahin, Nilfer; Edgünlü, Tuba (Springer Science and Business Media B.V., 2022)Vesicle-mediated membrane traffic is the mechanism fundamental to many biological events, especially the release of neurotransmitters. The main proteins of the mechanism that mediates membrane fusion in vesicle-mediated ...