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dc.contributor.authorSahin, Cagdas
dc.contributor.authorYildirim, Nuri
dc.contributor.authorAkdemir, Ali
dc.contributor.authorOzsener, Serdar
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorErbas, Oytun
dc.date.accessioned2020-11-20T14:39:46Z
dc.date.available2020-11-20T14:39:46Z
dc.date.issued2020
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.urihttps://doi.org/10.4274/jtgga.galenos.2019.2018.0121
dc.identifier.urihttps://hdl.handle.net/20.500.12809/570
dc.descriptionsahin, cagdas/0000-0001-7346-3987en_US
dc.descriptionWOS: 000519555600008en_US
dc.descriptionPubMed ID: 31088044en_US
dc.description.abstractObjective: Tadalafil is a selective phosphodiesterase type-5 inhibitor with a long half-life. It has a dual function in ischaemic and re-perfused tissues, i.e. vasodilatation and anti-oxidant effects. These features of tadalafil distinguish it from other anti-oxidants. We investigated the dual effect of tadalafil on ischaemia and reperfusion injury in the rat ovary. Material and Methods: We established five study groups. Group 1 (n=6): sham-operated; group 2 (n=6): torsion; group 3 (n=6): torsion and Tadalafil; group 4 (n=6): torsion/de-torsion; and group 5 (n=6): torsion/de-torsion and tadalafil. Ovarian samples were harvested from animals and evaluated in terms of histopathologic changes, tissue malondialdehyde (MDA) concentrations, lactate production, and plasma cyclic guanosine monophosphate (cGMP). Results: Follicular degeneration, oedema, haemorrhage, and inflammatory cells were significantly decreased in group 5 in comparison with group 4. Group 2 and group 3 were compared in terms of vascular congestion and haemorrhage; these parameters were significantly decreased in group 3. In addition, significantly decreased MDA and lactate concentrations were observed in group 5 in comparison with group 4. Increased cGMP concentrations were detected in group 3 and group 5. Conclusion: We conclude that tadalafil might be useful in protecting the ovary against ischaemia and reperfusion injury. In the evet of ovarian torsion, it will provide a greater therapeutic effect than only performing de-torsion of the ovary or using other anti-oxidant agents.en_US
dc.item-language.isoengen_US
dc.publisherGalenos Yayinciliken_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhosphodiesterase Type-5en_US
dc.subjectTadalafilen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectVasodilatationen_US
dc.subjectAnti-Oxidanten_US
dc.titleTadalafil attenuates ischemic damage as well as reperfusion injury in the rat ovaryen_US
dc.item-typearticleen_US
dc.contributor.departmenten_US
dc.contributor.departmentTemp[Sahin, Cagdas; Yildirim, Nuri; Akdemir, Ali; Ozsener, Serdar] Ege Univ, Dept Obstet & Gynecol, Fac Med, Izmir, Turkey -- [Yigitturk, Gurkan] Mugla Sitki Kocman Univ, Dept Histol & Embryol, Fac Med, Mugla, Turkey -- [Erbas, Oytun] Demiroglu Bilim Univ, Dept Physiol, Fac Med, Istanbul, Turkeyen_US
dc.identifier.doi10.4274/jtgga.galenos.2019.2018.0121
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.startpage35en_US
dc.identifier.endpage40en_US
dc.relation.journalJournal of the Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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