dc.description.abstract | Background: The aim of the study was to evaluate the effects of the using bisphosphonate, vitamin D, and a combination of bisphosphonate and vitamin D on fracture healing, by comparison of radiological and histological findings of the study groups and a control group. Methods: A total of 24 rats were randomly divided into 4 groups. A mid-third fracture was created in the femur of all rats. Saline was administered to Group A, bisphosphonate (Alendronate) to Group B, bisphosphonate (Alendronate) + vitamin D (Calcitriol) to Group C and vitamin D (Calcitriol) to Group D. All preparations were administered orally for 28 days. Results: No statistically significant difference was determined between the groups in respect of the effect on fracture healing according to radiological findings. The histological findings of fracture healing showed Groups B and C to be significantly more advanced than Group A (p = 0.017, p = 0.009). However no significant difference was found in Group D comparison with Group A (p = 0.224). Conclusion: According to the histological findings, advanced fracture healing was seen in the groups administered with bisphosphonate or combined bisphosphonate and vitamin D compared to the use of vitamin D alone and the control group. It was concluded that bisphosphonate treatment combined with vitamin D can be used safely without any negative effect on fracture healing. © 2016 Delhi Orthopedic Association. | en_US |
dc.contributor.departmentTemp | Aydoğan, N.H., Department of Orthopedics, Mugla Sitki Kocman University, Mugla, Turkey; Özel, I., Department of Orthopedics, Simav Public Hospital, Kütahya, Turkey; Iltar, S., Department of Orthopedics, Ankara Training and Research Hospital, Ankara, Turkey; Kara, T., Department of Orthopedics, Ankara Training and Research Hospital, Ankara, Turkey; Özmeriç, A., Department of Orthopedics, Ankara Training and Research Hospital, Ankara, Turkey; Alemdaroğlu, K.B., Department of Orthopedics, Ankara Training and Research Hospital, Ankara, Turkey | en_US |