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dc.contributor.authorKargun, Kursat
dc.contributor.authorDemir, Betul
dc.contributor.authorÇiçek, Demet
dc.contributor.authorKara, Murat
dc.contributor.authorBilik, Leyla
dc.contributor.authorKaya, Haktan
dc.date.accessioned2020-11-20T17:17:36Z
dc.date.available2020-11-20T17:17:36Z
dc.date.issued2017
dc.identifier.issn0970-938X
dc.identifier.urihttps://hdl.handle.net/20.500.12809/6485
dc.description.abstractPsoriasis is a chronic inflammatory disease with genetic transmission, the etiology of which has not been completely clarified yet. Insulin-like Growth Factor Binding Protein 2 (IGF2BP2) plays a role in growth, development, cellular differentiation, and cellular metabolism, and IGF2BP2 gene exists on the 3rd chromosome. In the present study, we aimed to investigate the rs1470579 and rs4402960 gene polymorphisms of IGF2BP2 in patients with psoriasis, which were confirmed to be related with insulin resistance. The study was conducted with a total of 100 patients diagnosed with psoriasis who were between the ages of 18 to 60 years and 100 healthy volunteers as controls. Blood samples of the participants were isolated and Deoxyribonucleic Acid (DNA) samples were obtained and analysed using y the real-time Polymerase Chain Reaction (PCR) method with TaqMan probes for rs1470579 and rs4402960 polymorphisms. There was no statistically significant difference in the genotype and allele distributions of the rs1470579 and rs4402960 regions of IGF2BP2 between the groups (p>0.05). However, there was a statistically significant difference in triglyceride and Low-Density Lipoprotein (LDL) levels between the groups (p<0.001). rs1470579 and rs4402960 gene polymorphisms of IGF2BP2, which are considered to play a role in the course of type 2 diabetes mellitus, were not determined to be risk factors for the pathogenesis of psoriasis. © 2017, Scientific Publishers of India. All rights reserved.en_US
dc.item-language.isoengen_US
dc.publisherScientific Publishers of Indiaen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIGF2BP2en_US
dc.subjectPolymorphismen_US
dc.subjectPsoriasisen_US
dc.subjectReal time PCRen_US
dc.titleIGF2BP2 gene polymorphism in patients with psoriasisen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Tıp Fakültesi, Dahili Tıp Bilimlerien_US
dc.contributor.institutionauthorÇiçek, Demet
dc.contributor.institutionauthorKara, Murat
dc.identifier.volume28en_US
dc.identifier.issue8en_US
dc.identifier.startpage3619en_US
dc.identifier.endpage3622en_US
dc.relation.journalBiomedical Research (India)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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