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dc.contributor.authorErdogan, Mumin A.
dc.contributor.authorTaskiran, Emin
dc.contributor.authorYiğittürk, Gürkan
dc.contributor.authorErbas, Oytun
dc.contributor.authorTaskiran, Dilek
dc.date.accessioned2020-11-20T14:40:37Z
dc.date.available2020-11-20T14:40:37Z
dc.date.issued2020
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.urihttps://doi.org/10.1002/jbt.22415
dc.identifier.urihttps://hdl.handle.net/20.500.12809/779
dc.descriptionTaskiran, Dilek/0000-0002-4505-0939; Erdogan, Mumin/0000-0003-0048-444Xen_US
dc.descriptionWOS: 000493863700001en_US
dc.descriptionPubMed ID: 31682045en_US
dc.description.abstractThe aim of this study was to assess the therapeutic potential of oxytocin and liraglutide (LIR), a GLP-1 analogue, in a rat model of vincristine-induced neuropathy. Rats were injected with vincristine (VCR) at a dose of 4 mg/kg twice a week for 5 weeks. The VCR-administered rats were divided into three groups and received saline, oxytocin, or liraglutide simultaneously with VCR. After the treatment period, electrophysiological, biochemical, histological, and immunohistochemical investigations were performed. Electromyography (EMG) recordings demonstrated significant alterations in the VCR + saline group (p < .001). Also, motor performance was decreased in the VCR + saline group (p < .05). Histologically, the axonal diameter was decreased in all groups. VCR + saline group showed significantly increased lipid peroxidation and decreased nerve growth factor (NGF) expression. However, the administration of oxytocin and liraglutide significantly prevented the EMG alterations, lipid peroxidation, and reduction in neuronal NGF expression. On the basis of these findings, oxytocin and liraglutide may be considered as potential agents for the prevention of VCR-induced neuropathy.en_US
dc.item-language.isoengen_US
dc.publisherWileyen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGLP-1en_US
dc.subjectLiraglutideen_US
dc.subjectNeuropathyen_US
dc.subjectOxytocinen_US
dc.subjectVincristineen_US
dc.titleThe investigation of therapeutic potential of oxytocin and liraglutide on vincristine-induced neuropathy in ratsen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorYiğittürk, Gürkan
dc.identifier.doi10.1002/jbt.22415
dc.identifier.volume34en_US
dc.identifier.issue1en_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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