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dc.contributor.authorTanoglu, Oguzhan
dc.contributor.authorSay, Ferhat
dc.contributor.authorYucens, Mehmet
dc.contributor.authorAlemdaroglu, Kadir Bahadir
dc.contributor.authorIltar, Serkan
dc.contributor.authorAydoğan, Nevres Hürriyet
dc.date.accessioned2020-11-20T14:40:47Z
dc.date.available2020-11-20T14:40:47Z
dc.date.issued2020
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.urihttps://doi.org/10.1007/s12011-019-01913-1
dc.identifier.urihttps://hdl.handle.net/20.500.12809/813
dc.descriptionTanoglu, Oguzhan/0000-0001-8984-9008; YUCENS, Mehmet/0000-0001-6924-6613; Aydogan, Nevres Hurriyet/0000-0002-1837-2676; Say, Ferhat/0000-0002-8021-0942en_US
dc.descriptionWOS: 000490887600002en_US
dc.descriptionPubMed ID: 31621008en_US
dc.description.abstractTitanium alloy implants are the most used materials for the fixation of lower extremity fractures. Although these implants were thought to be inert materials in vitro, several studies have shown increased serum and remote tissue metal ion levels due to wear of implants and friction of the bone-implant interface in vivo. The aim of this study was to investigate the alteration of serum metal ion levels that are released from intramedullary nails and plates used for the fixation of lower extremity fractures, within the fracture healing period. The study included 20 adult patients, who were treated with intramedullary nail or plate osteosynthesis due to closed lower extremity fractures. Alterations of serum titanium, aluminum, molybdenum, and vanadium levels were evaluated at 6, 12, 18, and 24 weeks postoperatively. A statistically significant increase was determined in serum titanium, aluminum, molybdenum, and vanadium ion levels in the intramedullary nail and plate groups at the end of the follow-up period. Pairwise comparisons of metal ion levels between implant groups revealed no significant difference during a 24-week follow-up period. Compared to the control group, statistically significant increased levels of serum titanium, aluminum, vanadium, and molybdenum ions were determined in the implant groups used for the fixation of lower extremity fractures at the end of 24 weeks. In the current literature, the potential toxic effects of prolonged exposure to low levels of these metal ions are still unknown. It can be predicted that long-term metal ion exposure could result in vivo pathological processes in the future.en_US
dc.description.sponsorshipTurkish Society of Orthopaedics and Traumatology (TSOT); Turkish Orthopaedics Research Council (TORC)en_US
dc.description.sponsorshipThis research was funded by the Turkish Society of Orthopaedics and Traumatology (TSOT) and Turkish Orthopaedics Research Council (TORC).en_US
dc.item-language.isoengen_US
dc.publisherHumana Press Incen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTitaniumen_US
dc.subjectAluminumen_US
dc.subjectVanadiumen_US
dc.subjectMolybdenumen_US
dc.subjectTrace Elementsen_US
dc.titleTitanium Alloy Intramedullary Nails and Plates Affect Serum Metal Ion Levels within the Fracture Healing Perioden_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorAydoğan, Nevres Hürriyet
dc.identifier.doi10.1007/s12011-019-01913-1
dc.identifier.volume196en_US
dc.identifier.issue1en_US
dc.identifier.startpage60en_US
dc.identifier.endpage65en_US
dc.relation.journalBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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