Yazar "Demircan, Turan" için listeleme
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Association between the anthropometric measurements and dietary habits on telomere shortening in healthy older adults: A-cross-sectional study
Barçın-Güzeldere, Hatice Kübra; Aksoy, Meral; Demircan, Turan; Yavuz, Mervenur; Beler, Mahmut (John Wiley and Sons Inc, 2023)im: This study aimed to evaluate the effect of anthropometric measurements and dietary habits on telomere length in healthy older residents in rural and urban areas. Methods: This was a cross-sectional study. The study ... -
Axolotl: A resourceful vertebrate model for regeneration and beyond
Bölük, Aydın; Yavuz, Mervenur; Demircan, Turan (WILEY, 2022)The regenerative capacity varies significantly among the animal kingdom. Successful regeneration program in some animals results in the functional restoration of tissues and lost structures. Among the highly regenerative ... -
Cellular and Molecular Comparison of Glioblastoma Multiform Cell Lines
Demircan, Turan; Yavuz, Mervenur; Kaya, Egemen; Akgül, Sıddıka; Altuntaş, Ebru (CUREUS INC, 2021)Glioblastoma multiform (GBM) is one of the most severe tumor types. It is highly invasive and characterized as a grade IV neoplastic cancer. Its resistance to chemotherapy-temozolomide (TMZ treatment)-in combination with ... -
Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl
Sibai, Mustafa; Altuntas, Ebru; Süzek, Barış Ethem; Sahin, Betul; Parlayan, Cuneyd; Ozturk, Gurkan; Demircan, Turan (Academic Press Inc Elsevier Science, 2020)The axolotl (Ambystoma mexicanum) salamander, a urodele amphibian, has an exceptional regenerative capacity to fully restore an amputated limb throughout the life-long lasting neoteny. By contrast, when axolotls are ... -
Dissecting the Molecular Signature of Spinal Cord Regeneration in the Axolotl Model
Demircan, Turan (Cureus Inc, 2020)Thousands of people are affected by central nervous system (CNS) dysfunctions each year, with stroke and spinal cord injury (SCI) being the most frequent causes. Although there is some evidence of partial CNS self-repair ... -
Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl
Demircan, Turan; Bay, Sadık; Öztürk, Gürkan; Emekli, Nesrin (Elsevier Inc., 2023)The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ growth, apoptosis, and cell cycle. Transcription coregulator component of Hippo pathway, YAP1, ... -
The first report on circulating microRNAs at Pre- and Post-metamorphic stages of axolotls
Demircan, Turan; Sibai, Mustafa; Avşaroğlu, Mahmut Erhan; Altuntaş, Ebru; Ovezmyradov, Guvanch (Elsevier B.V., 2020)MicroRNAs (miRNAs) are endogenously coded small RNAs, implicated in post-transcriptional gene regulation by targeting messenger RNAs (mRNAs). Circulating miRNAs are cell-free molecules, found in body fluids, such as blood ... -
Hydroquinidine displays a significant anticarcinogenic activity in breast and ovarian cancer cells via inhibiting cell-cycle and stimulating apoptosis
Yavuz, Mervenur; Demircan, Turan; Şahin, Betül; Baykal, Ahmet Tarık (TUBITAK, 2023)Breast and ovarian cancers are women’s most commonly diagnosed cancers. Seeking an efficient anticarcinogenic compound is still a top priority regarding the aggressiveness of these cancers and the limited benefit of current ... -
In vitro anti-carcinogenic effect of andarine as a selective androgen receptor modulator on MIA-PaCa-2 cells by decreased proliferation and cell-cycle arrest at G0/G1 phase
Bölük, Aydın; Yavuz, Mervenur; Demircan, Turan; Takanlou, Maryam Sabour; Avcı, Çığır Biray (Elsevier Ltd, 2023)Pancreatic cancer (PC) continues to be devastating due to its highly malignant nature and poor prognosis. The limited benefits of the chemotherapeutic drugs and increasing resistance pose a critical challenge to overcome ... -
Integrative Analysis of Axolotl Gene Expression Data from Regenerative and Wound Healing Limb Tissues
Sibai, Mustafa; Parlayan, Cüneyd; Tuğlu, Pelin; Özturk, Gürkan; Demircan, Turan (Nature Research, 2019)Axolotl (Ambystoma mexicanum) is a urodele amphibian endowed with remarkable regenerative capacities manifested in scarless wound healing and restoration of amputated limbs, which makes it a powerful experimental model for ... -
m 6 A Pathway Regulators Are Frequently Mutated in Breast Invasive Carcinoma and May Play an Important Role in Disease Pathogenesis
Demircan, Turan; Yavuz, Mervenur; Akgül, Sıddıka (Mary Ann Liebert, 2021)Breast invasive carcinoma (BIC) is one of the most commonly observed and the deadliest cancer among women. Studies examining the role of epigenetics and regulation of gene expression stand to make important strides in ... -
Microbiome and Longevity: High Abundance of Longevity-Linked Muribaculaceae in the Gut of the Long-Living RodentSpalax leucodon
Sibai, Mustafa; Altuntaş, Ebru; Yıldırım, Berna; Öztürk, Gürkan; Yıldırım, Süleyman; Demircan, Turan (Mary Ann Liebert, Inc, 2020)With a world population living longer as well as marked disparities in life expectancy, understanding the determinants of longevity is one of the priority research agendas in 21st century life sciences. To this end, the ... -
A potent ion channel blocker, hydroquinidine, exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
Yavuz, Mervenur; Demircan, Turan (Springer Science and Business Media B.V., 2023)Background: Despite recent advances in drug discovery, cancer is still one of the most lethal health problems worldwide. In most cases, standard therapy methods and multi-modal treatments fail, and new therapeutic approaches ... -
Preclinical Molecular Signatures of Spinal Cord Functional Restoration: Optimizing the Metamorphic Axolotl (Ambystoma mexicanum) Model in Regenerative Medicine
Demircan, Turan; Hacibektasogu, Harbiye; Sibai, Mustafa; Fescioglu, Ece Cana; Altuntaş, Ebru; Ozturk, Gurkan; Süzek, Barış Ethem (Mary Ann Liebert, Inc, 2020)Regenerative medicine offers hope for patients with diseases of the central and peripheral nervous system. Urodele amphibians such as axolotl display an exceptional regenerative capacity and are considered as essential ... -
Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
Demircan, Turan; Sibai, Mustafa; Altuntas, Ebru (Elsevier, 2020)The presented data article reports protein expression profiles during a time course of limb regeneration in the highly regenerative neotenic and regeneration-deficient metamorphic axolotl (Ambystoma mexicanum). A protein ... -
A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling pathway
Yavuz, Mervenur; Takanlou, Leila Sabour; Avcı, Çığır Biray; Demircan, Turan (Elsevier B.V., 2023)Hepatocellular carcinoma (HCC) is a major global health problem that often correlates with poor prognosis. Due to the insufficient therapy options with limited benefits, it is crucial to identify new therapeutic approaches ...
