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The effects of PKI-402 on breast tumor models' radiosensitivity via dual inhibition of PI3K/mTOR

Gasimli, Roya; Kayabaşı, Çağla; Yelken, Besra Özmen; Asık, Aycan (INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2023)

PurposePI3K/Akt/mTOR pathway activation causes relapse and resistance after radiotherapy in breast cancer (BC). We aimed to radiosensitize BC cell lines to irradiation (IR) by PKI-402, a dual PI3K/mTOR inhibitor.MethodsWe ...