Yazar "Tuinstra, Robbyn L." için listeleme
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An engineered second disulfide bond restricts lymphotactin/XCL1 to a chemokine-like conformation with XCR1 agonist activity
Tuinstra, Robbyn L.; Peterson, Francis C.; Elgin, Emine Sonay; Pelzek, Adam J.; Volkman, Brian F. (Amer Chemical Soc, 2007)Chemokines adopt a conserved tertiary structure stabilized by two disulfide bridges and direct the migration of leukocytes. Lymphotactin (Ltn) is a unique chemokine in that it contains only one disulfide and exhibits ... -
Interconversion between two unrelated protein folds in the lymphotactin native state
Tuinstra, Robbyn L.; Peterson, Francis C.; Kutlesa, Snjezana; Sonay Elgin, Emine; Kron, Michael A.; Volkman, Brian F. (Natl Acad Sciences, 2008)Proteins often have multiple functional states, which might not always be accommodated by a single fold. Lymphotactin (Ltn) adopts two distinct structures in equilibrium, one corresponding to the canonical chemokine fold ...
