Yazar "Tuli, Hardeep Singh" için listeleme
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Antimicrobial screening to molecular docking of newly synthesized ferrocenyl-substituted pyrazole
Sharma, Shashi; Tuli, Hardeep Singh; Varol, Mehmet (QASSIM UNIV, 2022)Objective: Microbial diseases are snowballing at an alarming proportion. Therefore, the intent of this study was to inspect the antimicrobial action of ferrocenyl-substituted pyrazole against various human pathogenic ... -
Chemopreventive mechanisms of amentoflavone: recent trends and advancements
Tuli, Hardeep Singh; Joshi, Hemant; Vashishth, Kanupriya; Ramniwas, Seema; Varol, Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)In parallel to the continuous rise of new cancer cases all over the world, the interest of scientific community in natural anticancer agents has steadily been increased. In the past decades, numerous phytochemicals have ... -
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies
Tuli, Hardeep Singh; Mittal, Sonam; Loka, Mariam; Aggarwal, Vaishali; Aggarwal, Diwakar; Masurkar, Akshara; Kaur, Ginpreet; Varol, Mehmet; Sak, Katrin; Kumar, Manoj; Sethi, Gautam; Bishayee, Anupam (Elsevier, 2021)Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties. Deguelin, a natural ... -
Emodin: A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets
Tuli, Hardeep Singh; Aggarwal, Vaishali; Tuorkey, Muobarak; Aggarwal, Diwakar; Parashar, Nidarshana Chaturvedi; Varol, Mehmet; Savla, Raj; Kaur, Ginpreet; Mittal, Sonam; Sak, Katrin (Elsevier, 2021)Oncogenic transformation has been the major cause of global mortality since decades. Despite established therapeutic regimes, majority of cancer patients either present with tumor relapse, refractory disease or therapeutic ... -
Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone
Varol, Mehmet; Tuli, Hardeep Singh; Kumar, Ajay; Sak, Katrin; Aggarwal, Diwakar; Gupta, Dhruv Sanjay; Çapanoğlu,Esra (MDPI, 2022)It is well known that, historically, plants have been an important resource of anticancer agents, providing several clinically approved drugs. Numerous preclinical studies have shown a strong anticancer potential of ... -
Licorice ( Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
Tuli, Hardeep Singh; Garg, Vivek Kumar; Mehta, Jinit K.; Kaur, Ginpreet; Mohapatra, Ranjan K.; Varol, Mehmet (Dove Press, 2022)Cancer is a highly lethal disease, and its incidence has rapidly increased worldwide over the past few decades. Although chemotherapeutics and surgery are widely used in clinical settings, they are often insufficient to ... -
Metal nanoparticles in cancer: from synthesis and metabolism to cellular interactions
Tuli, Hardeep Singh; Joshi, Ruchira; Kaur, Ginpreet; Garg, Vivek Kumar; Sak, Katrin; Varol,Mehmet (SPRINGER HEIDELBERG, 2022)Nanotechnology has encouraged new and amended materials (metal nanoparticles) for therapeutic applications with specific prominence in healthcare. Metal nanoparticles (NPs) are versatile nanoscale entities, widely used to ... -
NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target
Aggarwal, Vaishali; Tuli, Hardeep Singh; Varol, Mehmet (Elsevier, 2021)Notch signaling, an evolutionarily conserved signaling cascade, is critical for normal biological processes of cell differentiation, development, and homeostasis. Deregulation of the Notch signaling pathway has been ... -
Organotin (IV) complexes derived from Schiff base 1,3-bis[(1E)-1-(2-hydroxyphenyl)ethylidene] thiourea: synthesis, spectral investigation and biological study to molecular docking
Abbas, Zahoor; Tuli, Hardeep Singh; Varol, Mehmet; Sharma, Shashi (Springer, 2021)A novel Schiff base-derived organotin (IV) complexes have been synthesized by reacting 1, 3-bis [(1E)-1-(2-hydroxyphenyl) ethylidene]thiourea (which in turn obtained by condensing thiourea with ortho-hydroxyacetophenone) ... -
Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance
Tuli, Hardeep Singh; Mittal, Sonam; Aggarwal, Diwakar; Parashar, Gaurav; Parashar, Nidarshana Chaturvedi; Upadhyay, Sushil Kumar; Sharma, Anil Kumar; Varol, Mehmet (Academic Press, 2020)In the last few decades, targeting cancer by the use of dietary phytochemicals has gained enormous attention. The plausible reason and believe or mind set behind this fact is attributed to either lesser or no side effects ... -
Phloretin, as a Potent Anticancer Compound: From Chemistry to Cellular Interactions
Tuli, Hardeep Singh; Rath, Prangya; Chauhan, Abhishek; Ramniwas, Seema; Vashishth, Kanupriya; Varol, Mehmet (MDPI, 2022)Phloretin is a natural dihydrochalcone found in many fruits and vegetables, especially in apple tree leaves and the Manchurian apricots, exhibiting several therapeutic properties, such as antioxidant, antidiabetic, ... -
Polymer-mediated nanoformulations: a promising strategy for cancer immunotherapy
Kaur, Simranjit; Saini, Adesh K.; Tuli, Hardeep Singh; Garg, Nancy; Joshi, Hemant; Varol, Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)Engineering polymer-based nano-systems have attracted many researchers owing to their unique qualities like shape, size, porosity, mechanical strength, biocompatibility, and biodegradability. Both natural and synthetic ... -
Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements
Aggarwal, Vaishali; Tuli, Hardeep Singh; Varol, Ayşegül; Thakral, Falak; Yerer, Mükerrem Betül; Sak, Katrin; Sethi, Gautam; Varol, Mehmet (Mdpi, 2019)Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate regulation between the silver lining of low and high ROS concentration ... -
STAT signaling as a target for intervention: from cancer inflammation and angiogenesis to non-coding RNAs modulation
Tuli, Hardeep Singh; Sak, Katrin; Iqubal, Ashif; Garg, Vivek Kumar; Varol, Mehmet; Sharma, Uttam (SPRINGER, 2022)As a landmark, scientific investigation in cytokine signaling and interferon-related anti-viral activity, signal transducer and activator of transcription (STAT) family of proteins was first discovered in the 1990s. Today, ... -
Synthesis, Structural Investigations, and In Vitro/In Silico Bioactivities of Flavonoid Substituted Biguanide: A Novel Schiff Base and Its Diorganotin (IV) Complexes
Abbas, Zahoor; Kumar, Manoj; Tuli, Hardeep Singh; M Janahi, Essam; Haque, Shafiul ; Harakeh, Steve; Varol, Mehmet (MDPI, 2022)Quercetin is one of the most powerful bioactive dietary flavonoids. The in vivo biological study of quercetin is extremely difficult due to its very low solubility. However, diorganotin complexes of quercetin are more ...
