Yazar "Varol, Mehmet" için listeleme
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Anti-breast cancer and anti-angiogenic potential of a lichen-derived small-molecule: barbatolic acid
Varol, Mehmet (Springer, 2018)Natural products have been used for centuries as the most potent remedies to cure many diseases including cancer diseases. Angiogenesis is defined as the formation of new capillaries from existing vessels and plays a key ... -
Anti-lung Cancer and Anti-angiogenic Activities of New Designed Boronated Phenylalanine Metal Complexes
Varol, Mehmet; Koparal, Ayşe Tansu; Benkli, Kadriye; Bostancioğlu, Rakibe Beklem (Bentham Science Publ Ltd, 2018)Background: Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the long-term side effects. Objective: A ... -
Antimicrobial screening to molecular docking of newly synthesized ferrocenyl-substituted pyrazole
Sharma, Shashi; Tuli, Hardeep Singh; Varol, Mehmet (QASSIM UNIV, 2022)Objective: Microbial diseases are snowballing at an alarming proportion. Therefore, the intent of this study was to inspect the antimicrobial action of ferrocenyl-substituted pyrazole against various human pathogenic ... -
Blockage of ultraviolet B-induced damage in human keratinocytes by a lichen compound norstictic acid
Candan, M.; Varol, A.; Koparal, A. T.; Varol, Mehmet; Tay, T. (Wiley-Blackwell, 2016)[No abstract available] -
Cell-extracellular matrix adhesion assay
Varol, Mehmet (Humana Press Inc., 2020)Adhesion is defined as a fundamental ability of the adherent cells isolated from the multicellular organisms to attach to an extracellular matrix or another cell, and it takes a key role in a wide variety of the important ... -
Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments
Varol, Ayşegül; Sezen, Serap; Evcimen, Dilhan; Zarepour, Atefeh; Ulus, Gönül; Zarrabi, Ali; Orbayoğlu, Asya Gülistan; Varol, Mehmet (TAYLOR & FRANCIS INC, 2022)Bee venom therapy is known as a traditional approach to curing many medical conditions such as arthritis, pain and rheumatism. Bee venom also provides promising potential for treating many cancers such as breast, lung, ... -
Chemopreventive mechanisms of amentoflavone: recent trends and advancements
Tuli, Hardeep Singh; Joshi, Hemant; Vashishth, Kanupriya; Ramniwas, Seema; Varol, Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)In parallel to the continuous rise of new cancer cases all over the world, the interest of scientific community in natural anticancer agents has steadily been increased. In the past decades, numerous phytochemicals have ... -
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies
Tuli, Hardeep Singh; Mittal, Sonam; Loka, Mariam; Aggarwal, Vaishali; Aggarwal, Diwakar; Masurkar, Akshara; Kaur, Ginpreet; Varol, Mehmet; Sak, Katrin; Kumar, Manoj; Sethi, Gautam; Bishayee, Anupam (Elsevier, 2021)Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties. Deguelin, a natural ... -
Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents
Varol, Mehmet; Benkli, Kadriye; Koparal, Ayse T.; Bostancıoğlu, Rakibe B. (Taylor & Francis Ltd, 2019)Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. ... -
Emodin: A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets
Tuli, Hardeep Singh; Aggarwal, Vaishali; Tuorkey, Muobarak; Aggarwal, Diwakar; Parashar, Nidarshana Chaturvedi; Varol, Mehmet; Savla, Raj; Kaur, Ginpreet; Mittal, Sonam; Sak, Katrin (Elsevier, 2021)Oncogenic transformation has been the major cause of global mortality since decades. Despite established therapeutic regimes, majority of cancer patients either present with tumor relapse, refractory disease or therapeutic ... -
Evaluation of Multifunctional Hybrid Analogs for Stilbenes, Chalcones and Flavanones
Çağır, Ali; Odacı, Burcu; Varol, Mehmet; Akçok, İsmail; Okur, Özgür; Koparal, Ayse T. (Bentham Science Publ Ltd, 2017)Aims: In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel ... -
Evaluation of the sunscreen lichen substances usnic acid and atranorin
Varol, Mehmet; Tay, Turgay; Candan, Mehmet; Turk, Aysen; Koparal, Ayse Tansu (Inst Histol Embriol-Conicet, 2015)Usnic acid and atranorin are known as both sunscreen substances in natural lichen population and cytotoxic substances on human cell lines. Both substances were isolated from the acetone extracts of Cladonia foliacea and ... -
Gut Microbiota-Assisted Synthesis, Cellular Interactions and Synergistic Perspectives of Equol as a Potent Anticancer Isoflavone
Varol, Mehmet; Tuli, Hardeep Singh; Kumar, Ajay; Sak, Katrin; Aggarwal, Diwakar; Gupta, Dhruv Sanjay; Çapanoğlu,Esra (MDPI, 2022)It is well known that, historically, plants have been an important resource of anticancer agents, providing several clinically approved drugs. Numerous preclinical studies have shown a strong anticancer potential of ... -
Lichens as a Promising Source of Unique and Functional Small Molecules for Human Health and Well-Being
Varol, Mehmet (Elsevier Science Bv, 2018)Drug design and discovery processes are very important for human health because of the prevalence of many diseases for which there is no known medical cure. Much scientific effort backed by the financial support of governments ... -
Licorice ( Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
Tuli, Hardeep Singh; Garg, Vivek Kumar; Mehta, Jinit K.; Kaur, Ginpreet; Mohapatra, Ranjan K.; Varol, Mehmet (Dove Press, 2022)Cancer is a highly lethal disease, and its incidence has rapidly increased worldwide over the past few decades. Although chemotherapeutics and surgery are widely used in clinical settings, they are often insufficient to ... -
Metal nanoparticles in cancer: from synthesis and metabolism to cellular interactions
Tuli, Hardeep Singh; Joshi, Ruchira; Kaur, Ginpreet; Garg, Vivek Kumar; Sak, Katrin; Varol,Mehmet (SPRINGER HEIDELBERG, 2022)Nanotechnology has encouraged new and amended materials (metal nanoparticles) for therapeutic applications with specific prominence in healthcare. Metal nanoparticles (NPs) are versatile nanoscale entities, widely used to ... -
Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements
Aggarwal, Vaishali; Tuli, Hardeep S.; Thakral, Falak; Singhal, Paavan; Aggarwal, Diwakar; Srivastava, Saumya; Sethi, Gautam; Pandey, Anjana; Sak, Katrin; Varol, Mehmet; Khan, Md. Asaduzzaman (Sage Publications Ltd, 2020)Hesperidin belongs to flavanones class of flavonoids and is known to possess broad-spectrum applicability to prevent dreadful diseases such as cardiovascular disease, neurodegeneration, and cancer. The reported anticancer ... -
Nanomaterials-mediated oxidative stress in cancer: Recent trends and future perspectives
Varol, Tuğba Ören; Varol, Mehmet (Pan Stanford Publishing Pte. Ltd, 2022)The malignant tissue that is formed as a result of carcinogenesis, which causes the cells to continuously increase their dividing capacity by exhibiting abnormal behavior, may damage the surrounding tissues and prevent ...
