Yazar "Volkman, Brian F." için listeleme
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E2-binding surface on Uba3 beta-grasp domain undergoes a conformational transition
Elgin, E. Sonay; Sokmen, Nazli; Peterson, Francis C.; Volkman, Brian F.; Dag, Cagdas; Haas, Arthur L. (Wiley-Blackwell, 2012)The covalent attachment of ubiquitin (Ub) and ubiquitin-like (Ubl) proteins to various eukaryotic targets plays critical roles in regulating numerous cellular processes. E1-activating enzymes are critical, because they ... -
An engineered second disulfide bond restricts lymphotactin/XCL1 to a chemokine-like conformation with XCR1 agonist activity
Tuinstra, Robbyn L.; Peterson, Francis C.; Elgin, Emine Sonay; Pelzek, Adam J.; Volkman, Brian F. (Amer Chemical Soc, 2007)Chemokines adopt a conserved tertiary structure stabilized by two disulfide bridges and direct the migration of leukocytes. Lymphotactin (Ltn) is a unique chemokine in that it contains only one disulfide and exhibits ... -
Identification and characterization of a glycosaminoglycan recognition element of the C chemokine lymphotactin
Peterson, Francis C.; Elgin, Emine Sonay; Nelson, Timothy J.; Zhang, Fuming; Hoeger, Theresa J.; Linhardt, Robert J.; Volkman, Brian F. (Amer Soc Biochemistry Molecular Biology Inc, 2004)Chemokine-mediated recruitment of leukocytes in vivo depends on interactions with cell surface glycosaminoglycans. Lymphotactin, the unique member of the "C" chemokine subclass, is a highly basic protein that binds heparin, ... -
Interconversion between two unrelated protein folds in the lymphotactin native state
Tuinstra, Robbyn L.; Peterson, Francis C.; Kutlesa, Snjezana; Sonay Elgin, Emine; Kron, Michael A.; Volkman, Brian F. (Natl Acad Sciences, 2008)Proteins often have multiple functional states, which might not always be accommodated by a single fold. Lymphotactin (Ltn) adopts two distinct structures in equilibrium, one corresponding to the canonical chemokine fold ...
