Screening of Beta-glucosidase inhibitors and their Chemical Profiles from Marine sediment Bacteria

Abstract

The marine environment can be a valuable resource of secondary metabolites. The request for novel natural products and their application in public health has received increased attention. Novel natural products with potential as therapeutic agents have been extracted and identified from marine resources. In this study, marine bacteria were investigated for ss-glucosidase inhibitors. A total of 58 bacterial species of the genus Bacillus, Peribacillus, Brevibacterium, Alkalihalobacillus, Oceanobacillus, Metabacillus, Kocuria, Micrococcus, Lacisediminihabitans, Rhodococcus, Halobacillus and Marinibacillus were analysed by extracting inhibitor metabolites and agar-plate inhibition. Of these species, 42 produced inhibitors. The most active extracts contained alkaloids, phenolics, flavonoids and terpenoids. The total alkaloid, phenolic, flavonoid and terpenoid contents of the extracts ranged from 3.46 to 274.83 mg equivalent boldine/g extract, 65.30 to 170.32 mg equivalent gallic acid/g extract, 8.94 to 38.64 mg equivalent quercetin/g extract 1.92 to 100.74 mg equivalent linaool/g extract. Based on our findings, marine bacterial extracts contain effective inhibitors of ss-glucosidase.