Lack of association between sirtuin gene variants and endometrial cancer

Abstract

Cancer of the endometrium is the most common gynecological cancer in women. The pathophysiology of the disease has not yet been clearly defined, and the pathways leading to endometrial carcinoma are not fully understood. Sirtuins are stress-responsive proteins that direct various post-translational modifications (PTMs) and, as a result, are master regulators of several cellular processes. Studies conducted on the SIRT1 enzyme and genetic expressions have revealed data on apoptosis and autophagy mechanisms as well as other actions on the cell. The purpose of our study was to investigate the relationship between rs7895833, rs7069102, and rs2273773 polymorphisms of the SIRT1 gene and endometrial cancer. This study took paraffin-embedded endometrium specimens from 48 endometrial cancer patients and 53 healthy control subjects. SIRT1 gene variants were determined with the PCR-CCTP method. The result of the single-nucleotide polymorphism (SNP) analysis indicated no significant relationship with endometrial cancer. Recent studies have shown that SIRT has had a positive effect on endometrial tumors. Our study analyzed, for the first time, the association between SIRT1 gene polymorphisms and endometrial cancer. Because of the low population our results are not reflecting the exact contribution of the polymorphism to the development of the disease, further studies need to be performed with higher population numbers. Therefore, further studies on a larger population in cohort studies will be required to confirm whether polymorphism is a potential novel genetic marker.