Temel Tıp Bilimleri Bölümü Koleksiyonu
Recent Submissions
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Platelet-Rich Plasma in Vitrification; is it Helpful or Harmful?
(University of Agriculture, 2023)Human and animal studies on cryoprotectants and freezing solutions are still needed to establish a simple yet reliable protocol and increase the success of cryopreservation. The main aim of this study was to evaluate the ... -
Long-Term Prophylactic Transcranial Direct Current Stimulation Ameliorates Allodynia and Improves Clinical Outcomes in Individuals With Migraine
(ELSEVIER, 2023)Objectives: Migraine is a common and substantially debilitating disorder that may associate with allodynia, a marker of central sensitization in the pain circuits. Several unmet needs, like limited adherence to drugs due ... -
Demonstration of ameliorating effect of papaverine in sepsis-induced acute lung injury on rat model through radiology and histology
(Turkish Association of Trauma and Emergency Surgery (TATES), 2023)Background: Our target was to show the role of high mobility group box-1/receptor for (HMGB1/RAGE) interaction in feces intraperitoneal injection procedure (FIP)-induced acute lung injury (ALI) pathophysiology, to investigate ... -
Lacosamide exhibits neuroprotective effects in a rat model of Parkinson's disease
(Journal of Chemical Neuroanatomy, 2023)Background: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder that primarily affects the motor system. Although there are several treatments available to alleviate PD symptoms, there is ... -
Antioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity in Wistar rats
(Elsevier Ltd, 2023)Doxorubicin (DXR) is widely used in cancer treatment. However, it has not yet been possible to prevent the side effects of DXR. The aim of this study was to investigate the hepatoprotective effect of crocin against DXR ... -
The effects of PKI-402 on breast tumor models' radiosensitivity via dual inhibition of PI3K/mTOR
(INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2023)PurposePI3K/Akt/mTOR pathway activation causes relapse and resistance after radiotherapy in breast cancer (BC). We aimed to radiosensitize BC cell lines to irradiation (IR) by PKI-402, a dual PI3K/mTOR inhibitor.MethodsWe ... -
Assessment of biological rhythm disturbances and emotion recognition in individuals with or without obstructive sleep apnea syndrome: The role of eating patterns
(Taylor and Francis Ltd., 2023)Although a vast amount of research efforts including a plethora of distinct methodologies have been put forth, the pathophysiology of obstructive sleep apnea syndrome (OSAS) has not been compromised and multidimensional ... -
Conversion of specific lncRNAs to biomarkers in exhaled breath condensate samples of patients with advanced stage non-small-cell lung cancer
(PMC, 2023)Lung cancer (LC) is one of the most prevalent cancers with the highest fatality rate worldwide. Long noncoding RNAs (lncRNAs) are being considered potential new molecular targets for early diagnosis, follow-up, and individual ... -
Association between the anthropometric measurements and dietary habits on telomere shortening in healthy older adults: A-cross-sectional study
(John Wiley and Sons Inc, 2023)im: This study aimed to evaluate the effect of anthropometric measurements and dietary habits on telomere length in healthy older residents in rural and urban areas. Methods: This was a cross-sectional study. The study ... -
A new strategy to achieve high antimicrobial activity: green synthesised silver nanoparticle formulations with Galium aparine and Helichrysum arenarium
(SCIENDO, 2023)Silver nanoparticles (AgNPs), which have recently gained attention due to their antimicrobial activity, can also be produced by green synthesis. The aims of this study were to (i) characterise green synthesized AgNPs using ... -
Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl
(Elsevier Inc., 2023)The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ growth, apoptosis, and cell cycle. Transcription coregulator component of Hippo pathway, YAP1, ... -
In vitro anti-carcinogenic effect of andarine as a selective androgen receptor modulator on MIA-PaCa-2 cells by decreased proliferation and cell-cycle arrest at G0/G1 phase
(Elsevier Ltd, 2023)Pancreatic cancer (PC) continues to be devastating due to its highly malignant nature and poor prognosis. The limited benefits of the chemotherapeutic drugs and increasing resistance pose a critical challenge to overcome ... -
Butyrylcholinesterase in lipid metabolism: A new outlook
(WILEY, 2023)Cholinesterase enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are traditionally associated with the termination of acetylcholine mediated neural signaling. The fact that these ubiquitous enzymes are ... -
A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling pathway
(Elsevier B.V., 2023)Hepatocellular carcinoma (HCC) is a major global health problem that often correlates with poor prognosis. Due to the insufficient therapy options with limited benefits, it is crucial to identify new therapeutic approaches ... -
The Healing Effect of Digoxin on Peripheral Nerve Damage and Its Relation to IL-17/IL-10
(Turkish Neurosurgical Society, 2023)AIM: To demonstrate the curative effect of digoxin on peripheral nerve damage with its anti-inflammatory role on interleukin (IL)-17. MATERIAL and METHODS: The study was conducted with 30 male Sprague Dawley albino mature ... -
Age-Related Characterization of Dental Pulp Mesenchymal Stem Cells
(WILEY, 2023)Age-Related Characterization... -
Effect of Transcranial Direct Current Stimulation on Pain and Physical Functions in Individuals with Lumbar Spinal Stenosis: A Double-Blind Randomized Sham-controlled Study
(WILEY, 2023)Effect of Transcranial Direct Current Stimulation.... -
Tetrachloromethane Induced Acute Liver Injury in Mice: Biochemical and Histopathological Study of the Hepatoprotective Effect of Hep-X Standardized Botanical Dietary Supplement
(Springer, 2023)This work was aimed at investigating the hepatoprotective effect of Hep-X, a polyherbal formulation containing Silybum marianum L. (Milk thistle), Rosmarinus officinalis L. (Rosemary), Curcuma longa L. (Turmeric) and Fumaria ... -
Transcranial direct current stimulation combined with cognitive training improves decision making and executive functions in opioid use disorder: a triple-blind sham-controlled pilot study
(Taylor and Francis Ltd., 2023)Background: Opioid use disorder (OUD) is a chronic disorder with a considerable amount of morbidity and mortality. Despite remarkable improvement achieved by maintenance programs, an array of treatment goals were still ... -
Hydroquinidine displays a significant anticarcinogenic activity in breast and ovarian cancer cells via inhibiting cell-cycle and stimulating apoptosis
(TUBITAK, 2023)Breast and ovarian cancers are women’s most commonly diagnosed cancers. Seeking an efficient anticarcinogenic compound is still a top priority regarding the aggressiveness of these cancers and the limited benefit of current ...
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