Relation Between Red Cell Distribution Width and Severity of Coronary Artery Disease in Patients With Acute Myocardial Infarction

Abstract

Increased red blood cell distribution width (RDW) has been associated with adverse outcomes in acute myocardial infarction (AMI). We evaluated the relationship between RDW and severity of coronary artery disease (CAD) in patients with AMI. We analyzed the relation between RDW and angiographic severity of CAD. Patients (n = 580) with elevated Syntax scores (SSs >32) had higher RDW values (15.1% +/- 1.7% vs 14.1 +/- 1.7%, P < .001). The SS was positively correlated with RDW level (r = .252, P < .001) and neutrophil/lymphocyte (N/L) ratio (r = .178, P < .001). There was a mild significant association between RDW level and N/L ratio (r = .106, P = .033). In the multiple logistic regression analysis, RDW (odds ratio = 1.165, 95% confidence interval 1.02-1.32, P = .021) remained a significant predictor for the severity of CAD. Red blood cell distribution width, an inexpensive and easily measurable laboratory variable, is independently associated with the severity of CAD in patients with AMI.