Effect of Atorvastatin on Hematologic Parameters in Patients With Hypercholesterolemia

Abstract

Hematologic parameters such as mean platelet volume (MPV), red cell distribution width (RDW), and neutrophil to lymphocyte (N/L) ratio are associated with increased cardiovascular risk. We investigated the effect of atorvastatin on hematologic parameters in patients with hypercholesterolemia. A total of 79 patients with hypercholesterolemia and 47 normocholesterolemic healthy participants were included. Patients with hypercholesterolemia received 10 to 80 mg/d atorvastatin during a 24-week period. Hematologic parameters were measured at baseline and after 6 months. Atorvastatin treatment produced a significant decrease in MPV levels (9.3 +/- 1.3 vs 9.1 +/- 1.2 fL, P = .008) and platelet count (259 +/- 61 vs 248 +/- 51 10(9)/L, P = .005). The N/L ratio decreased significantly after atorvastatin treatment from 2.9 +/- 1.2 to 2.6 +/- 1.1, (P = .014). The RDW and platelet distribution width levels were not different among the study groups, before and after treatment. Atorvastatin may beneficially reduce MPV levels and N/L ratio. This antiplatelet and anti-inflammatory effect of atorvastatin treatment could play a role in reducing cardiovascular risk.