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dc.contributor.authorUğur, Aysel
dc.contributor.authorCeylan, Özgür
dc.date.accessioned2020-11-20T16:45:23Z
dc.date.available2020-11-20T16:45:23Z
dc.date.issued2003
dc.identifier.issn0188-4409
dc.identifier.issn1873-5487
dc.identifier.urihttps://doi.org/10.1016/S0188-4409(03)00006-7
dc.identifier.urihttps://hdl.handle.net/20.500.12809/5390
dc.descriptionWOS: 000182686100007en_US
dc.descriptionPubMed ID: 12700009en_US
dc.description.abstractBackground. Presence of staphylococci resistant to antibiotics is of concern, as is the possible spread of resistance determinants among Staphylococcus species. During the past several years, a series of staphylococcal isolates that demonstrated reduced susceptibility to vancomycin or other glycopeptides has been reported. However, there are no useful data on species sensitivity of coagulase-negative staphylococci to heavy metals. Methods. A total of 22 Staphylococcus spp. isolates recovered from clinical sources was studied for antibiotic and heavy metal resistance patterns and plasmid profiles. Isolated strains were biochemically identified by conventional tests followed by use of API Staph system. Isolates were tested for antimicrobial susceptibility by standard methods. Resistance patterns to nickel chloride (NiCl2), zinc sulfate (ZnSO4), lead acetate Pb(CH3COO)(2), cobalt chloride (COCl2), copper sulfate (CUSO4), potassium chromate (K2Cr2O7), silver nitrate (AgNO3), and mercuric chloride (HgCl2) were surveyed by agar-dilution method. Plasmid DNA was prepared according to a previously described modification of alkaline lysis procedure. Results. In this study, isolated strains included eight (36.4%) Staphylococcus Xylosus, five (22.7%) Staphylococcus aureus, four (18.2%) nonidentifiable Staphylococcus spp., one (4.5%) Staphylococcus capitis, one (4.5%) Staphylococcus lentus, one (4.5%) Staphylococcus epidermidis, one (4.5%) Staphylococcus sciuri, and one (4.5%) Staphylococcus chromogenes. All strains showed widest resistance profile to both antibiotics and metals. Methicillin resistance of Staphylococcus aureus (MRSA) was 40%. Resistance to oxacillin was 53% in coagulase-negative staphylococci (CNS) strains. No isolate was resistant to vancomycin. All isolates were resistant to K(2)Cr(2)QO(7.) and Pb(CH3COO)(2); on the other hand, all isolates were sensitive to AgNO3. Highest incidence of metal-antibiotic multiple 661 . Plasmid content resistance existed between K2Cr2O7, Pb(CH3COO)(2), and penicillin-G profile studies showed that isolates carried plasmids ranging from 2.224 to 20.650 kb in size. Conclusions. Fifty percent of studied strains harbored plasmids and association between occurence of plasmids and resistance to antibiotics and heavy,metals was observed. (C) 2003 IMSS. Published by Elsevier Science Inc.en_US
dc.item-language.isoengen_US
dc.publisherElsevier Science Incen_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibiotic resistanceen_US
dc.subjectHeavy metal resistanceen_US
dc.subjectPlasmidsen_US
dc.subjectStaphylococcus sppen_US
dc.subjectCoagulase-negative staphylococcien_US
dc.titleOccurrence of resistance to antibiotics, metals, and plasmids in clinical strains of Staphylococcus sppen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Fen Fakültesi, Biyoloji Bölümüen_US
dc.contributor.authorID0000-0002-1865-1093
dc.contributor.institutionauthorUğur, Aysel
dc.contributor.institutionauthorCeylan, Özgür
dc.identifier.doi10.1016/S0188-4409(03)00006-7
dc.identifier.volume34en_US
dc.identifier.issue2en_US
dc.identifier.startpage130en_US
dc.identifier.endpage136en_US
dc.relation.journalArchives of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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