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dc.contributor.authorGülsu, Aydan
dc.contributor.authorYüksektepe, Ecem
dc.date.accessioned2021-06-24T11:51:48Z
dc.date.available2021-06-24T11:51:48Z
dc.date.issued2021en_US
dc.identifier.citationGülsu, A. and E. Yüksektepe. 2021. "Preparation of Spherical Cellulose Nanoparticles from Recycled Waste Cotton for Anticancer Drug Delivery." ChemistrySelect 6 (22): 5419-5425. doi:10.1002/slct.202101683.en_US
dc.identifier.issn23656549
dc.identifier.urihttps://doi.org/10.1002/slct.202101683
dc.identifier.urihttps://hdl.handle.net/20.500.12809/9346
dc.description.abstractUsing natural waste resources as a starting material for the preparation of cellulose nanoparticles is a field of interest for novel pharmaceutical applications. This study aims to introduce cellulose nanoparticles for Doxorubicin (DOX) delivery to tumor cells. Cellulose nanocrystals were first produced from waste cotton by hydrochloric acid (1 M) hydrolysis, and then spherical cellulose nanoparticles were prepared by microemulsion method. The prepared particles were spherical with 300 nm in size, and the zeta potential was −12.5 mV. The drug entrapment efficiency was ∼99 % (w/w). DOX loaded particles exhibited a biphasic release pattern at pH 7.4 phosphate buffer without initial burst effect. Release experiments demonstrated that DOX release was up to 34 days (97 %). In vitro cytotoxicity assay on human A549 (human lung adenocarcinoma) cell line was performed by MTT assay. The results show that prepared particles are effective on cancer cells. It is important in terms of economic and environmental problems that the material prepared for use in cancer drug release presented here is obtained from the waste cotton.en_US
dc.item-language.isoengen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.isversionof10.1002/slct.202101683en_US
dc.item-rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCellulose nanoparticlesen_US
dc.subjectCytotoxicityen_US
dc.subjectDOXen_US
dc.subjectDrug deliveryen_US
dc.subjectMicroemulsion methoden_US
dc.subjectWaste cottonen_US
dc.titlePreparation of Spherical Cellulose Nanoparticles from Recycled Waste Cotton for Anticancer Drug Deliveryen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.contributor.authorID0000-0001-5026-6868en_US
dc.contributor.institutionauthorGülsu, Aydan
dc.contributor.institutionauthorYüksektepe, Ecem
dc.identifier.volume6en_US
dc.identifier.issue22en_US
dc.identifier.startpage5419en_US
dc.identifier.endpage5425en_US
dc.relation.journalChemistrySelecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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