Chemical constituents from fruits of Cnestis ferruginea Vahl ex. DC (Connaraceae) and evaluation of their anticholinesterase and antiradical activities
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2022Author
Maleu, Thérèse ChristelleTalla, Rostan Mangoua
Kamdem, Michael Hermann Kengne
Ngenge, Tamfu Alfred
Küçükaydın, Selçuk
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Thérèse Christelle Maleu, Rostan Mangoua Talla, Michael Hermann Kengne Kamdem, Tamfu Alfred Ngenge, Selcuk Kucukaydin, Edwin Mpho Mmutlane, Derek Tantoh Ndinteh, Celine Djama Mbazoa & Jean Wandji (2022): Chemical constituents from fruits of Cnestis ferruginea Vahl ex. DC (Connaraceae) and evaluation of their anticholinesterase and antiradical activities, Natural Product Research, DOI: 10.1080/14786419.2022.2048299Abstract
The phytochemical investigation of the DCM/MeOH (1:1) extract of the fruits of Cnestis ferruginea led to the isolation and characterization of one new quinic acid derivative, ferruginoic acid (1), together with six known compounds 2-7. Compounds 3-7 were reported for the first time from this species. The structures of compounds 1-7 were elucidated on the basis of 1 D and 2 D NMR spectroscopic data, mass spectrometry and by comparison of spectroscopic data with those from the literature. The anticholinesterase (AChE and BChE) activity and DPPH free radical scavenging assay of compounds 1, 3, 4 and 7 were evaluated. Ferruginoic acid (1) exhibited moderate anticholinesterase activity with IC50 value of 36.18 +/- 1.78 mu g/mL against AChE. Compounds 3, 4 and 7 showed high activity against free radical (DPPH center dot) scavenging assay (DPPH) with IC50 values 40.09 +/- 0.96 mu g/mL, 61.70 +/- 0.78 mu g/mL and 41.87 +/- 0.62 mu g/mL respectively. These results indicate that C. ferruginea and its constituents could be employed in the management of Alzheimer's disease.