• Türkçe
    • English
  • Türkçe 
    • Türkçe
    • English
  • Giriş
Öğe Göster 
  •   DSpace@Muğla
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • WoS İndeksli Yayınlar Koleksiyonu
  • Öğe Göster
  •   DSpace@Muğla
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • WoS İndeksli Yayınlar Koleksiyonu
  • Öğe Göster
JavaScript is disabled for your browser. Some features of this site may not work without it.

INVESTIGATION OF REELIN RS7341475, RS362691 AND RS12705169 GENE POLYMORPHISMS IN CASES A WITH SUICIDE ATTEMPT

Thumbnail

Göster/Aç

Tam metin / Full text (610.9Kb)

Tarih

2015

Yazar

Şahin, Cem
Kara, Murat
Kara, Bilge
Şahin, Nilfer
Beydilli, Halil
Acar, Ethem

Üst veri

Tüm öğe kaydını göster

Özet

Background: Suicidal ideations and behavior is one of the most serious conditions among psychiatric emergencies. Neurobiology and genetics of suicide attracted more interest in subsequent period. Today, studies focus on identification of related genes and polymorphisms at chromosomal level as a result of advances in molecular genetics. In this study, we aimed to investigate possible effects of reelin gene polymorphism on the pathogenesis of suicide attempts. Methods: This study included 106 patients with a suicide attempt and 90 healthy controls. Cases with a suicide attempt were assessed and classified by a clinician regarding the reason for a suicide, whether a suicide attempt was planned. The patients attempted to suicide by firearm or ingestion of toxic drug doses were considered as serious suicidal attempt. Reelin rs326691 (G/C), rs734147 (A/G) and rs12705169 (T/G) gene polymorphisms were examined by Real-PCR between patient and control groups. Homozygous mutant, heterozygous and homozygous normal genotypes were identified based on allele discrimination. Results: Of 106 patients with a suicide attempt, 23.6% were men and 76.4% were women. Median age was 20 years (12-52). In our study, it was demonstrated there was a significant difference in genotype and allele distribution of rs734147 gene polymorphism between the patient and control groups (p=0.004 and p=0.003). In addition, it was shown that both rs734147 and rs12705169 gene mutations were significantly more common in cases with serious suicidal attempts intending death when compared to those with suicide attempts seeking attention (p<0.001 and p=0.025). Conclusions: Our results indicated genetic variation of rs734147 and rs12705169 in reelin is significantly associated with the development of suicide attempt.

Kaynak

Acta Medica Mediterranea

Cilt

31

Sayı

5

Bağlantı

https://hdl.handle.net/20.500.12809/3185

Koleksiyonlar

  • Dahili Tıp Bilimleri Bölümü Koleksiyonu [691]
  • Scopus İndeksli Yayınlar Koleksiyonu [6219]
  • WoS İndeksli Yayınlar Koleksiyonu [6466]



DSpace software copyright © 2002-2015  DuraSpace
İletişim | Geri Bildirim
Theme by 
@mire NV
 

 




| Politika | Rehber | İletişim |

DSpace@Muğla

by OpenAIRE
Gelişmiş Arama

sherpa/romeo

Göz at

Tüm DSpaceBölümler & KoleksiyonlarTarihe GöreYazara GöreBaşlığa GöreKonuya GöreTüre GöreDile GöreBölüme GöreKategoriye GöreYayıncıya GöreErişim ŞekliKurum Yazarına GöreBu KoleksiyonTarihe GöreYazara GöreBaşlığa GöreKonuya GöreTüre GöreDile GöreBölüme GöreKategoriye GöreYayıncıya GöreErişim ŞekliKurum Yazarına Göre

Hesabım

GirişKayıt

DSpace software copyright © 2002-2015  DuraSpace
İletişim | Geri Bildirim
Theme by 
@mire NV
 

 


|| Politika || Rehber|| Yönerge || Kütüphane || Muğla Sıtkı Koçman Üniversitesi || OAI-PMH ||

Muğla Sıtkı Koçman Üniversitesi, Muğla, Türkiye
İçerikte herhangi bir hata görürseniz, lütfen bildiriniz:

Creative Commons License
Muğla Sıtkı Koçman Üniversitesi Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@Muğla:


DSpace 6.2

tarafından İdeal DSpace hizmetleri çerçevesinde özelleştirilerek kurulmuştur.