Yazar "Kara, Murat" için Tıp Fakültesi listeleme
-
The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells
Bayram, D.; Çetin, Esin Sakallı; Kara, Murat; Özgöçmen, M.; Candan, I. A. (Sage Publications Ltd, 2017)Background: Silibinin is a bioactive flavonolignan extracted from milk thistle, known as Silybum marianum. Silibinin exerts strong antiproliferative, proapoptotic, and anti-inflammatory effects. Many studies have shown ... -
Application of talcum powder, trichloroacetic acid and silver nitrate in female rats for non-surgical sterilization: evaluation of the apoptotic pathway mRNA and miRNA genes
Yumrutaş, Önder; Kara, Murat; Atılgan, Remzi; Kavak, Salih Burçin; Bozgeyik, İbrahim; Sapmaz, Ekrem (Wiley, 2015)There are several methods used for non-surgical sterilization in birth control including quinacrine, trichloroacetic acid (TCA), erythromycin, tetracycline, silver nitrate and talcum powder. Among these, talcum powder, TCA ... -
Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis
Kara, Murat; Yolbaş, Servet; Şahin, Cem; Koca, Süleyman Serdar (Aves, 2017)Objective: Sirtuins (SIRTs) play a prominent role in metabolism, apoptosis, aging, inflammation, and epigenetics. Inflammation, apoptosis, and epigenetics are pathogenic issues in rheumatoid arthritis (RA). This study aimed ... -
Cinsel istismar olgularında monoamin oksidaz A enziminin gen polimorfizmi ve davranım bozukluğu gelişmesi ile arasındaki ilişkinin incelenmesi
Özgür, Börte Gürbüz; Aksu, Hatice; Kara, Murat (2017)Amaç: Bu çalışmanın amacı cinsel istismar mağduru olan olgularda davranım bozukluğu (DB) geliştiren ve geliştirmeyen gruplar arasında monoamin oksidaz A (MAO-A) gen polimorfizmi açısından ilişki olup olmadığını incelemektir. ... -
Determination of the effects on learning and memory performance and related gene expressions of clothianidin in rat models
Özdemir, Hasan Hüseyin; Kara, Murat; Yumrutaş, Önder; Üçkardeş, Fatih; Eraslan, Ersen; Demir, Caner F.; Bal, Ramazan (Springer, 2014)Clothianidin (CLO) is one of the pesticides used to protect against insects, and its potential toxic effects on cognitive functions are not clearly known. This study aims to evaluate the possible effects of dose-dependent ... -
Differential Expression and in Silico Functional Analysis of Plasma MicroRNAs in the Pathogenesis of Non-segmental Vitiligo
Demir Pektaş, Suzan; Kara, Murat; Doğan, Gürsoy; Pektaş, Mehmet Bilgehan; Baloğlu, Mehmet Cengiz; Sadi, Gökhan (PMC, 2023)Vitiligo is a disease characterized by acquired depigmentation, white macules, and patches on the skin due to the dysfunction of epidermal melanocytes. In this study, we attempt to profile the microRNA (miRNA) expression ... -
Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma
Kara, Murat; Yumrutaş, Önder; Özcan, Önder; Çelik, Özgür İlhan; Bozgeyik, Esra; Bozgeyik, İbrahim; Taşdemir, Şener (Elsevier Science Bv, 2015)Colorectal cancer is one of the frequently seen malignancies in the world. To date, several oncogenes and tumor suppressor genes have been identified and linked to colorectal cancer pathogenesis. Although recent advances ... -
Ectodermal dysplasia-skin fragility syndrome with a new mutation
Alataş, Emine Tuğba; Kara, Asude; Kara, Murat; Doğan, Gürsoy; Baysal, Onur (Wolters Kluwer Medknow Publications, 2017) -
Endothelin-1 Lys198Asn and rs10478694 polymorphism in ischemic stroke
Aslan, Orhan; Gurger, Mehtap; Atescelik, Metin; Kara, Murat; Sen, Askin; Alataş, Ömer Doğan; Kargun, Kursat (Scientific Publishers of India, 2017)Objective: In this study, we aimed to investigate the relationship between ischemic cerebrovascular diseases and Lys198Asn and rs10478694 polymorphism of Endothelin-1 gene, a strong vasoconstrictor. Materials and Methods: ... -
Endothelin-1 Lys198Asn and rs10478694 polymorphism in ischemic stroke.
Aslan, Orhan; Gurger, Mehtap; Atescelik, Metin; Kara, Murat; Sen, Askin; Alatas, Omer Dogan; Kargun, Kursat (Scientific Publishers India, 2017)Objective: In this study, we aimed to investigate the relationship between ischemic cerebrovascular diseases and Lys198Asn and rs10478694 polymorphism of Endothelin-1 gene, a strong vasoconstrictor. Materials and Methods: ... -
ENHO gene expression and serum adropin level in rheumatoid arthritis and systemic lupus erythematosus
Yolbaş, Servet; Kara, Murat; Kalaycı, Mehmet; Yıldırım, Ahmet; Gündoğdu, Barış; Aydın, Süleyman; Koca, Suleyman Serdar (Wroclaw Medical Univ, 2018)Background. Adropin, a secreted protein, is encoded by the energy homeostasis-associated gene (ENHO). It is expressed by a variety of tissues and cells. It has been implicated in several physiological and pathological ... -
Evaluation of RELN gene polymorphism in children with autism spectrum disorder
Şahin, Nilfer; Kara, Murat; Kara, Bilge; Topal, Hatice (Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2018)Objective: With increasing frequency of autism spectrum disorder (ASD) in recent years, etiology has not yet been fully elucidated. Multiple hypotheses have been proposed to explain autism etiology including genetic, ... -
IGF2BP2 gene polymorphism in patients with morbid obesity
Kargün, Kürşat; Şenol, Sefa; Kırkıl, Cüneyt; Çambay, Zafer; Kara, Murat; Aygen, Erhan; Yılmaz, Mustafa (Allied Acad, 2017)Background/Aim: In this study, it was aimed to determine the relationship between morbid obesity and insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) rs1470579 and rs4402960 gene polymorphisms. Materials and ... -
IGF2BP2 gene polymorphism in patients with psoriasis
Kargun, Kursat; Demir, Betul; Çiçek, Demet; Kara, Murat; Bilik, Leyla; Kaya, Haktan (Scientific Publishers of India, 2017)Psoriasis is a chronic inflammatory disease with genetic transmission, the etiology of which has not been completely clarified yet. Insulin-like Growth Factor Binding Protein 2 (IGF2BP2) plays a role in growth, development, ... -
IGF2BP2 gene polymorphism in patients with psoriasis.
Kargun, Kursat; Demir, Betul; Cicek, Demet; Kara, Murat; Bilik, Leyla; Kaya, Haktan (Allied Acad, 2017)Psoriasis is a chronic inflammatory disease with genetic transmission, the etiology of which has not been completely clarified yet. Insulin-like Growth Factor Binding Protein 2 (IGF2BP2) plays a role in growth, development, ... -
The IL-33 gene is related to increased susceptibility to systemic sclerosis
Koca, Süleyman Serdar; Pehlivan, Yavuz; Kara, Murat; Alibaz-Öner, Fatma; Öztuzcu, Serdar; Yılmaz, Neslihan; Onat, Ahmet Mesut (Springer Heidelberg, 2016)Systemic sclerosis (SSc) is a chronic inflammatory disease characterized by widespread fibrosis of the skin and several visceral organs. The pro-fibrotic potential of interleukin (IL)-33 has been demonstrated by in both ... -
Influence of omega-3 fatty acid on orthodontic tooth movement in rats: A biochemical, histological, immunohistochemical and gene expression study
Öğrenim, Gözde; Cesur, Mine G.; Önal, Tuna; Kara, Murat; Şirin, Fevziye B.; Yalçın, Gizem D.; İnan, Sevinç (Wiley, 2019)Structured Abstract Objective The aim of this study was to investigate the effects of omega-3 fatty acids on orthodontic tooth movement. Setting and Sample Population For this study, 56 12-week-old adult male Wistar albino ... -
Insecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model
Kara, Murat; Yumrutaş, Önder; Demir, Caner F.; Özdemir, Hasan Hüseyin; Bozgeyik, İbrahim; Coşkun, Salih; Bal, Ramazan (Wiley, 2015)The potential toxic effects of several pesticides, including imidacloprid on non-target organisms have not been clearly established. Also, the chronic effects of non-toxic doses on cognitive function in mammals are unknown. ... -
INVESTIGATION OF REELIN RS7341475, RS362691 AND RS12705169 GENE POLYMORPHISMS IN CASES A WITH SUICIDE ATTEMPT
Şahin, Cem; Kara, Murat; Kara, Bilge; Şahin, Nilfer; Beydilli, Halil; Acar, Ethem (Carbone Editore, 2015)Background: Suicidal ideations and behavior is one of the most serious conditions among psychiatric emergencies. Neurobiology and genetics of suicide attracted more interest in subsequent period. Today, studies focus on ... -
Lack of association between increased mitochondrial DNA(4977) deletion and ATP levels of sputum cells from chronic obstructive pulmonary disease patients versus healthy smokers
Karimova, A.; Oltulu, Y. M.; Azaklı, H.; Kara, Murat; Ustek, D.; Tutluoglu, B.; Onaran, I. (Taylor & Francis Ltd, 2017)In this study we looked at smokers with and without chronic obstructive pulmonary disease (COPD) patients in order to evaluate the incidence of 4977 base pair (bp) mtDNA (mtDNA(4977)) deletion and mtDNA copy number in ...