Basit öğe kaydını göster

dc.contributor.authorMokaddem-Daroui, Habiba
dc.contributor.authorMostefa, Maya Belhadj
dc.contributor.authorAydoğmuş Öztürk, Fatma
dc.contributor.authorErol, Ebru
dc.contributor.authorÖztürk, Mehmet
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorDuru, Mehmet Emin
dc.contributor.authorKabouche, Ahmed
dc.contributor.authorKabouche, Zahia
dc.date.accessioned2021-06-10T10:10:00Z
dc.date.available2021-06-10T10:10:00Z
dc.date.issued2021en_US
dc.identifier.citationMokaddem-Daroui H, Belhadj Mostefa M, Ozturk M, Erol E, Aydogmus-Ozturk F, Ertaş A, Duru ME, Kabouche A, Kabouche Z. Antioxidant, anticholinesterase activities and polyphenolic constituents of cones of algerian fir (Abies numidica) by LC-ESI-MS/MS with chemometric approach. J Res Pharm. 2021; 25(3): 230-237.en_US
dc.identifier.urihttps://dx.doi.org/10.29228/jrp.13
dc.identifier.urihttps://hdl.handle.net/20.500.12809/9309
dc.description.abstractThe fractions (Fr.1-5) of the hydromethanolic extract of Abies numidica cones were studied for their polyphenol constituents, antioxidant, and anticholinesterase activities. The beta-carotene-linoleic acid, cupric reducing power (CUPRAC), DPPH scavenging, and ABTS radical scavenging assays were used to determine antioxidant activity. Fr.3 exhibited the highest antioxidant activity in ABTS test (IC50: 1.29 mu g/mL), b-carotene-linoleic acid test (IC50: 18.6 mu g/mL) and CUPRAC (A(0.5): 33.8 mu g/mL) assays. Three fractions (Fr.2-4) promising antioxidant activity were analyzed using LC-MS/MS for their phenolic compositions. Taxifolin (155.9-2816.2 mu g analyte/g extract), hyperoside (353.0-2045.5 mu g/g), vanillin (1488.9-1529.9 mu g/g), tannic acid (1281.6-1416.8 mu g/g), rosmarinic acid (1063.1-1149.3 mu g/g), coumarin (683.0-772.6 mu g/g), quercetin (881.0 mu g/g), and catechin (277.7-400.2 mu g/g) were identified in the antioxidant fractions. Moreover, the anticholinesterase activity was also performed using the in vitro spectroscopic Ellman method. The antioxidant fractions exhibited moderate butyrylcholinesterase inhibitory activity. The multi-ware analysis was performed to understand the origin of bioactivities. According to principal component analysis, it is detected that the hyperoside, catechin, taxifolin, and tannic acid were responsible for the antioxidant activity. Therefore, the cones of Abies numidica can be considered as potent antioxidant and anticholinesterase sources in food and pharmaceutical industries, commercially.en_US
dc.description.sponsorshipDGRSDT-MESRS (Algeria) 15/116 Mugla Sitki Kocman University 15/116en_US
dc.item-language.isoengen_US
dc.publisherMarmara Üniversitesien_US
dc.relation.isversionof10.29228/jrp.13en_US
dc.item-rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAbies numidicaen_US
dc.subjectLC-MS/MSen_US
dc.subjectAntioxidant activityen_US
dc.subjectAnticholinesterase activityen_US
dc.subjectTaxifolinen_US
dc.subjectHyperosideen_US
dc.titleAntioxidant, anticholinesterase activities and polyphenolic constituents of cones of algerian fir (Abies numidica) by LC-ESI-MS/MS with chemometric approachen_US
dc.item-typearticleen_US
dc.contributor.departmentMÜ, Fen Fakültesi, Kimya Bölümüen_US
dc.contributor.authorID0000-0001-6070-7452en_US
dc.contributor.authorID0000-0001-6342-4298en_US
dc.contributor.authorID0000-0001-8932-4535en_US
dc.contributor.institutionauthorAydoğmuş Öztürk, Fatma
dc.contributor.institutionauthorErol, Ebru
dc.contributor.institutionauthorÖztürk, Mehmet
dc.contributor.institutionauthorDuru, Mehmet Emin
dc.identifier.volume25en_US
dc.identifier.issue3en_US
dc.identifier.startpage230en_US
dc.identifier.endpage237en_US
dc.relation.journalJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster